PDB entry 1pww

View 1pww on RCSB PDB site
Description: Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
Class: hydrolase
Keywords: Anthrax Toxin, Lethal Factor (active site mutant), optimised peptide substrate, hydrolase
Deposited on 2003-07-02, released 2004-01-27
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.238
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: LEF OR PXO1-107
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15917 (Start-775)
      • engineered (686)
    Domains in SCOPe 2.02: d1pwwa1, d1pwwa2, d1pwwa3
  • Chain 'B':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: LEF OR PXO1-107
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15917 (Start-775)
      • engineered (686)
    Domains in SCOPe 2.02: d1pwwb1, d1pwwb2, d1pwwb3
  • Chain 'C':
    Compound: lf20
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1PWW
  • Chain 'D':
    Compound: lf20
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1PWW
  • Heterogens: ZN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pwwA (A:)
agghgdvgmhvkekeknkdenkrkdeernktqeehlkeimkhivkievkgeeavkkeaae
kllekvpsdvlemykaiggkiyivdgditkhislealsedkkkikdiygkdallhehyvy
akegyepvlviqssedyventekalnvyyeigkilsrdilskinqpyqkfldvlntikna
sdsdgqdllftnqlkehptdfsvefleqnsnevqevfakafayyiepqhrdvlqlyapea
fnymdkfneqeinlsleelkdqrmlsryekwekikqhyqhwsdslseegrgllkklqipi
epkkddiihslsqeekellkriqidssdflsteekeflkklqidirdslseeekellnri
qvdssnplsekekeflkklkldiqpydinqrlqdtgglidspsinldvrkqykrdiqnid
allhqsigstlynkiylyenmninnltatlgadlvdstdntkinrgifnefkknfkysis
snymivdinerpaldnerlkwriqlspdtragylengklilqrnigleikdvqiikqsek
eyiridakvvpkskidtkiqeaqlninqewnkalglpkytklitfnvhnryasnivesay
lilnewknniqsdlikkvtnylvdgngrfvftditlpniaeqythqdeiyeqvhskglyv
pesrsillhgpskgvelrndsegfihcfghavddyagylldknqsdlvtnskkfidifke
egsnltsygrtneaeffaeafrlmhstdhaerlkvqknapktfqfindqikfiins

    Sequence, based on observed residues (ATOM records): (download) 
    >1pwwA (A:)
nktqeehlkeimkhivkievkgeeavkkeaaekllekvpsdvlemykaiggkiyivdgdi
tkhislealsedkkkikdiygkdallhehyvyakegyepvlviqssedyventekalnvy
yeigkilsrdilskinqpyqkfldvlntiknasdsdgqdllftnqlkehptdfsvefleq
nsnevqevfakafayyiepqhrdvlqlyapeafnymdkfneqeinlsleelkdqrmlsry
ekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqidssd
flsteekeflkklqidilsekekeflkklkldiqpydinqrlqdtgglidspsinldvrk
qykrdiqnidallhqsigstlynkiylyenmninnltatlgadlvdstdntkinrgifne
fkknfkysissnymivdinerpaldnerlkwriqlspdtragylengklilqrnigleik
dvqiikqsekeyiridakvvpkskidtkiqeaqlninqewnkalglpkytklitfnvhnr
yasnivesaylilnewknniqsdlikkvtnylvdgngrfvftditlpniaeqythqdeiy
eqvhskglyvpesrsillhgpskgvelrndsegfihcfghavddyagylldknqsdlvtn
skkfidifkeegsnltsygrtneaeffaeafrlmhstdhaerlkvqknapktfqfindqi
kfiins

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1pwwB (B:)
agghgdvgmhvkekeknkdenkrkdeernktqeehlkeimkhivkievkgeeavkkeaae
kllekvpsdvlemykaiggkiyivdgditkhislealsedkkkikdiygkdallhehyvy
akegyepvlviqssedyventekalnvyyeigkilsrdilskinqpyqkfldvlntikna
sdsdgqdllftnqlkehptdfsvefleqnsnevqevfakafayyiepqhrdvlqlyapea
fnymdkfneqeinlsleelkdqrmlsryekwekikqhyqhwsdslseegrgllkklqipi
epkkddiihslsqeekellkriqidssdflsteekeflkklqidirdslseeekellnri
qvdssnplsekekeflkklkldiqpydinqrlqdtgglidspsinldvrkqykrdiqnid
allhqsigstlynkiylyenmninnltatlgadlvdstdntkinrgifnefkknfkysis
snymivdinerpaldnerlkwriqlspdtragylengklilqrnigleikdvqiikqsek
eyiridakvvpkskidtkiqeaqlninqewnkalglpkytklitfnvhnryasnivesay
lilnewknniqsdlikkvtnylvdgngrfvftditlpniaeqythqdeiyeqvhskglyv
pesrsillhgpskgvelrndsegfihcfghavddyagylldknqsdlvtnskkfidifke
egsnltsygrtneaeffaeafrlmhstdhaerlkvqknapktfqfindqikfiins

    Sequence, based on observed residues (ATOM records): (download) 
    >1pwwB (B:)
rnktqeehlkeimkhivkievkgeeavkkeaaekllekvpsdvlemykaiggkiyivdgd
itkhislealsedkkkikdiygkdallhehyvyakegyepvlviqssedyventekalnv
yyeigkilsrdilskinqpyqkfldvlntiknasdsdgqdllftnqlkehptdfsvefle
qnsnevqevfakafayyiepqhrdvlqlyapeafnymdkfneqeinlsleelkdqrmlsr
yekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqidss
dflsteekeflkklqidirdslsnplsekekeflkklkldiqpydinqrlqdtgglidsp
sinldvrkqykrdiqnidallhqsigstlynkiylyenmninnltatlgadlvdstdntk
inrgifnefkknfkysissnymivdinerpaldnerlkwriqlspdtragylengklilq
rnigleikdvqiikqsekeyiridakvvpkskidtkiqeaqlninqewnkalglpkytkl
itfnvhnryasnivesaylilnewknniqsdlikkvtnylvdgngrfvftditlpniaeq
ythqdeiyeqvhskglyvpesrsillhgpskgvelrndsegfihcfghavddyagylldk
nqsdlvtnskkfidifkeegsnltsygrtneaeffaeafrlmhstdhaerlkvqknapkt
fqfindqikfiins

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.