SCOPe 2.01: Structural Classification of Proteins

PDB entry 1h7w

View 1h7w on RCSB PDB site
Description: dihydropyrimidine dehydrogenase (dpd) from pig
Class: electron transfer
Keywords: electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, oxidoreductase
Deposited on 2001-01-19, released 2001-02-23
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.174
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.01: d1h7wa1, d1h7wa2, d1h7wa3, d1h7wa4, d1h7wa5
Chain 'B':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.01: d1h7wb1, d1h7wb2, d1h7wb3, d1h7wb4, d1h7wb5
Chain 'C':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.01: d1h7wc1, d1h7wc2, d1h7wc3, d1h7wc4, d1h7wc5
Chain 'D':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.01: d1h7wd1, d1h7wd2, d1h7wd3, d1h7wd4, d1h7wd5
Heterogens: SF4, FMN, FAD, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1h7wA (A:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1h7wA (A:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

Chain 'B':
Sequence, based on SEQRES records: (download)

>1h7wB (B:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1h7wB (B:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglp

Chain 'C':
Sequence, based on SEQRES records: (download)

>1h7wC (C:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1h7wC (C:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

Chain 'D':
Sequence, based on SEQRES records: (download)

>1h7wD (D:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1h7wD (D:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpl