SCOPe 2.08: Domain d1um9a_: 1um9 A:

Lineage for d1um9a_ (1um9 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Thermus thermophilus [TaxId:274] [102337] (4 PDB entries)

8. Domain d1um9a_: 1um9 A: [99581]
   Other proteins in same PDB: d1um9b1, d1um9b2, d1um9d1, d1um9d2
   complexed with so4

Details for d1um9a_

PDB Entry: 1um9, 2.2 Å

PDB Description: branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 in apo-form

PDB Compounds: (A:) 2-oxo acid dehydrogenase alpha subunit

SCOPe Domain Sequences for d1um9a_:

Sequence, based on SEQRES records:

>d1um9a_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Thermus thermophilus [TaxId: 274]}
hrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgkts
fiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkg
rqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwya
ginfaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdvlasyy
vvkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprfrrfle
arglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqeallke
el

Sequence, based on observed residues (ATOM records):

>d1um9a_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Thermus thermophilus [TaxId: 274]}
hrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgkts
fiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkg
rqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwya
ginfaavqgapavfiaennfptiadkahafgipgylvdgmdvlasyyvvkeaverarrge
gpslvelrvyrygphrkkdpiprfrrflearglwneeweedvreeiraelerglkeaeea
gpvppewmfedvfaekpwhllrqeallkeel

Timeline for d1um9a_:

• d1um9a_ first appeared in SCOP 1.67
  
• d1um9a_ appears in SCOPe 2.07