SCOPe 2.08: Protein: Branched-chain alpha-keto acid dehydrogenase, PP module

Lineage for Protein: Branched-chain alpha-keto acid dehydrogenase, PP module

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

Species:

Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries)
Uniprot P12694 52-445
1. Domain for 1dtw:
  - Domain d1dtwa_: 1dtw A: [31827]
    Other proteins in same PDB: d1dtwb1, d1dtwb2
    complexed with k, mg, tdp
2. Domain for 1ols:
  - Domain d1olsa_: 1ols A: [93331]
    Other proteins in same PDB: d1olsb1, d1olsb2
    complexed with gol, k, mn, tdp
3. Domain for 1olu:
  - Domain d1olua_: 1olu A: [93335]
    Other proteins in same PDB: d1olub1, d1olub2
    complexed with gol, k, mg, tdp
4. Domain for 1olx:
  - Domain d1olxa_: 1olx A: [93338]
    Other proteins in same PDB: d1olxb1, d1olxb2
    complexed with gol, k, mn, tdp
5. Domain for 1u5b:
  - Domain d1u5ba_: 1u5b A: [113034]
    Other proteins in same PDB: d1u5bb1, d1u5bb2
    complexed with gol, k, mn, tdp
6. Domain for 1v11:
  - Domain d1v11a_: 1v11 A: [108227]
    Other proteins in same PDB: d1v11b1, d1v11b2
    complexed with ben, cl, gol, k, mn, tdp
7. Domain for 1v16:
  - Domain d1v16a_: 1v16 A: [108240]
    Other proteins in same PDB: d1v16b1, d1v16b2
    complexed with ben, cl, gol, k, mn, tdp
8. Domain for 1v1m:
  - Domain d1v1ma_: 1v1m A: [108261]
    Other proteins in same PDB: d1v1mb1, d1v1mb2
    complexed with ben, cl, gol, k, mn, tdp
9. Domain for 1v1r:
  - Domain d1v1ra_: 1v1r A: [108272]
    Other proteins in same PDB: d1v1rb1, d1v1rb2
    complexed with cl, gol, k, na, so4
10. Domain for 1x7w:
  - Domain d1x7wa_: 1x7w A: [114938]
    Other proteins in same PDB: d1x7wb1, d1x7wb2
    complexed with cl, gol, k, mn, tdp
11. Domain for 1x7x:
  - Domain d1x7xa_: 1x7x A: [114941]
    Other proteins in same PDB: d1x7xb1, d1x7xb2
    complexed with cl, gol, k, mn, tdp
12. Domain for 1x7y:
  - Domain d1x7ya_: 1x7y A: [114944]
    Other proteins in same PDB: d1x7yb1, d1x7yb2
    complexed with cl, gol, k, mn, tdp
13. Domain for 1x7z:
  - Domain d1x7za_: 1x7z A: [114947]
    Other proteins in same PDB: d1x7zb1, d1x7zb2
    complexed with cl, gol, k, mn, tdp
14. Domain for 1x80:
  - Domain d1x80a_: 1x80 A: [114950]
    Other proteins in same PDB: d1x80b1, d1x80b2
    complexed with cl, gol, k, mn, tdp
15. Domain for 2bfb:
  - Domain d2bfba1: 2bfb A:6-400 [146139]
    Other proteins in same PDB: d2bfbb1, d2bfbb2
    complexed with cl, gol, k, mn, mrd, tdp
16. Domain for 2bfc:
  - Domain d2bfca1: 2bfc A:6-400 [144987]
    Other proteins in same PDB: d2bfcb1, d2bfcb2
    complexed with gol, k, mn, tzd
17. Domain for 2bfd:
  - Domain d2bfda1: 2bfd A:6-400 [144988]
    Other proteins in same PDB: d2bfdb1, d2bfdb2
    complexed with cl, gol, k, mn, mpd, tdp
18. Domain for 2bfe:
  - Domain d2bfea1: 2bfe A:6-400 [146140]
    Other proteins in same PDB: d2bfeb1, d2bfeb2
    complexed with cl, gol, k, mn, mrd, tdp
19. Domain for 2bff:
  - Domain d2bffa1: 2bff A:6-400 [144989]
    Other proteins in same PDB: d2bffb1, d2bffb2
    complexed with gol, k, mn, tzd
Thermus thermophilus [TaxId:274] [102337] (4 PDB entries)
1. Domains for 1um9:
  1. Domain d1um9a_: 1um9 A: [99581]
    Other proteins in same PDB: d1um9b1, d1um9b2, d1um9d1, d1um9d2
    complexed with so4
  2. Domain d1um9c_: 1um9 C: [99584]
    Other proteins in same PDB: d1um9b1, d1um9b2, d1um9d1, d1um9d2
    complexed with so4
2. Domains for 1umb:
  1. Domain d1umba_: 1umb A: [99587]
    Other proteins in same PDB: d1umbb1, d1umbb2, d1umbd1, d1umbd2
    complexed with mg, tdp
  2. Domain d1umbc_: 1umb C: [99590]
    Other proteins in same PDB: d1umbb1, d1umbb2, d1umbd1, d1umbd2
    complexed with mg, tdp
3. Domains for 1umc:
  1. Domain d1umca_: 1umc A: [99593]
    Other proteins in same PDB: d1umcb1, d1umcb2, d1umcd1, d1umcd2
    complexed with 4mv, mg, tdp
  2. Domain d1umcc_: 1umc C: [99596]
    Other proteins in same PDB: d1umcb1, d1umcb2, d1umcd1, d1umcd2
    complexed with 4mv, mg, tdp
4. Domains for 1umd:
  1. Domain d1umda_: 1umd A: [99599]
    Other proteins in same PDB: d1umdb1, d1umdb2, d1umdd1, d1umdd2
    complexed with coi, mg, tdp
  2. Domain d1umdc_: 1umd C: [99602]
    Other proteins in same PDB: d1umdb1, d1umdb2, d1umdd1, d1umdd2
    complexed with coi, mg, tdp

More info for Protein Branched-chain alpha-keto acid dehydrogenase, PP module from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module

Timeline for Protein Branched-chain alpha-keto acid dehydrogenase, PP module from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module:

Protein Branched-chain alpha-keto acid dehydrogenase, PP module from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module first appeared in SCOP 1.65
Protein Branched-chain alpha-keto acid dehydrogenase, PP module from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module appears in SCOPe 2.07