Lineage for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108723Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Domains:

  1. 21087242-oxoisovalerate dehydrogenase (E1B), PP module [88769] (1 species)
    chain A is alpha-subunit and chain B is beta-subunit
  2. 2108727Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)
    1. 2108728Species Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries)
      Uniprot P12694 52-445
    2. 2108748Species Thermus thermophilus [TaxId:274] [102337] (4 PDB entries)
  3. 2108757E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
  4. 2108792Pyruvate dehydrogenase E1-alpha, PdhA [117525] (1 species)
  5. 2108802automated matches [190098] (3 species)
    not a true protein
    1. 2108803Species Bacillus stearothermophilus [TaxId:1422] [188729] (3 PDB entries)
    2. 2108816Species Human (Homo sapiens) [TaxId:9606] [186820] (5 PDB entries)
    3. 2108823Species Pseudomonas putida [TaxId:303] [186989] (1 PDB entry)

More info for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module

Timeline for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module: