Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 protein domains)
    members organized in the groups and subfamiles specified by the comments

Protein Domains:

  1. 19292333-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. 1929262Abelsone tyrosine kinase (abl) [56166] (2 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. 1929263Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [56167] (7 PDB entries)
  3. 1929289Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. 1929306Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. 1929370B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. 1929376Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 1929380c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. 1929413c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. 1929422c-src tyrosine kinase [56155] (2 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. 1929423Species Chicken (Gallus gallus) [TaxId:9031] [56157] (39 PDB entries)
    2. 1929502Species Human (Homo sapiens) [TaxId:9606] [56156] (12 PDB entries)
  10. 1929520Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. 1929523cAMP-dependent PK, catalytic subunit [56116] (5 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. 1929524Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. 1929526Species Cow (Bos taurus) [TaxId:9913] [56118] (40 PDB entries)
      Uniprot P00517
    3. 1929569Species Mouse (Mus musculus) [TaxId:10090] [56119] (29 PDB entries)
    4. 1929603Species Norway rat (Rattus norvegicus) [TaxId:10116] [256101] (1 PDB entry)
    5. 1929605Species Pig (Sus scrofa) [TaxId:9823] [56117] (9 PDB entries)
  12. 1929618Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. 1929630Casein kinase-1, CK1 [56139] (4 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. 1929631Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. 1929636Species Human (Homo sapiens) [TaxId:9606] [224941] (9 PDB entries)
    3. 1929661Species Mouse (Mus musculus) [TaxId:10090] [197326] (1 PDB entry)
    4. 1929664Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. 1929669Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. 1929735Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  16. 1929741Cell division protein kinase 9, CDK9 [160810] (1 species)
  17. 1929749Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. 1929750Species Human (Homo sapiens) [TaxId:9606] [88856] (348 PDB entries)
      Uniprot P24941
    2. 1930189Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
  18. 1930198Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  19. 1930210Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  20. 1930227Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  21. 1930250Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  22. 1930278Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  23. 1930282EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  24. 1930361epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  25. 1930365ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  26. 1930369Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  27. 1930429Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  28. 1930468Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  29. 1930471Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. 1930472Species Chicken (Gallus gallus) [TaxId:9031] [187336] (2 PDB entries)
    2. 1930475Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)
  30. 1930498G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  31. 1930509gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  32. 1930514Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  33. 1930589Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  34. 1930627Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  35. 1930676Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  36. 1930698Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  37. 1930748Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  38. 1930786MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  39. 1930838MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 1930839Species Human (Homo sapiens) [TaxId:9606] [56135] (13 PDB entries)
    2. 1930860Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (27 PDB entries)
  40. 1930891MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 1930892Species Human (Homo sapiens) [TaxId:9606] [56130] (162 PDB entries)
    2. 1931072Species Mouse (Mus musculus) [TaxId:10090] [56131] (23 PDB entries)
  41. 1931096MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  42. 1931100Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  43. 1931104Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  44. 1931107Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  45. 1931116pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  46. 1931148Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  47. 1931170Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase
  48. 1931173Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. 1931174Species Human (Homo sapiens) [TaxId:9606] [75559] (45 PDB entries)
    2. 1931236Species Maize (Zea mays) [TaxId:4577] [56143] (32 PDB entries)
    3. 1931274Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)
  49. 1931279Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase
  50. 1931284Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  51. 1931360Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  52. 1931363Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase
  53. 1931371Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)
  54. 1931374Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  55. 1931385STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  56. 1931391Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  57. 1931395Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  58. 1931399Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. 1931400Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. 1931402Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  59. 1931405Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  60. 1931430Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  61. 1931488Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  62. 1931549Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  63. 1931552Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  64. 1931583automated matches [190091] (12 species)
    not a true protein
    1. 1931584Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (9 PDB entries)
    2. 1931601Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)
    3. 1931604Species Chicken (Gallus gallus) [TaxId:9031] [187329] (6 PDB entries)
    4. 1931611Species Cow (Bos taurus) [TaxId:9913] [187007] (28 PDB entries)
    5. 1931650Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)
    6. 1931653Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [258686] (2 PDB entries)
    7. 1931656Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)
    8. 1932435Species Maize (Zea mays) [TaxId:4577] [195345] (1 PDB entry)
    9. 1932437Species Mouse (Mus musculus) [TaxId:10090] [187169] (35 PDB entries)
    10. 1932494Species Mycobacterium tuberculosis [TaxId:1773] [225570] (2 PDB entries)
    11. 1932498Species Mycobacterium tuberculosis [TaxId:419947] [226040] (7 PDB entries)
    12. 1932509Species Oryza sativa [TaxId:39947] [256089] (1 PDB entry)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: