SCOPe 2.05: Protein: EGF receptor tyrosine kinase, Erbb-1

Lineage for Protein: EGF receptor tyrosine kinase, Erbb-1

Root: SCOPe 2.05
Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
shares functional and structural similarities with the ATP-grasp fold and PIPK
Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
members organized in the groups and subfamiles specified by the comments
Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

Species:

Human (Homo sapiens) [TaxId:9606] [82796] (65 PDB entries)
Uniprot P00533 702-1018
1. Domain for 1m14:
  - Domain d1m14a_: 1m14 A: [78367]
2. Domain for 1m17:
  - Domain d1m17a_: 1m17 A: [78370]
    complexed with aq4
3. Domain for 1xkk:
  - Domain d1xkka_: 1xkk A: [115409]
    complexed with fmm, po4
4. Domain for 2eb2:
  - Domain d2eb2a_: 2eb2 A: [163929]
    automated match to d1m14a_
5. Domain for 2eb3:
  - Domain d2eb3a_: 2eb3 A: [163930]
    automated match to d1m14a_
    complexed with anp
6. Domain for 2gs2:
  - Domain d2gs2a_: 2gs2 A: [135574]
    automated match to d1m14a_
7. Domain for 2gs6:
  - Domain d2gs6a_: 2gs6 A: [135578]
    automated match to d1m14a_
    complexed with 112, cl
8. Domains for 2gs7:
  1. Domain d2gs7a_: 2gs7 A: [164827]
    automated match to d1m14a_
    complexed with anp, iod, mg
  2. Domain d2gs7b_: 2gs7 B: [164828]
    automated match to d1m14a_
    complexed with anp, iod, mg
9. Domain for 2ity:
  - Domain d2itya1: 2ity A:697-1018 [137648]
    automatically matched to d1m14a_
    complexed with ire
10. Domain for 2rfe:
  - Domain d2rfed_: 2rfe D: [168080]
    automated match to d1m14a_
11. Domain for 2rgp:
  - Domain d2rgpa_: 2rgp A: [206100]
    automated match to d3gt8b_
    complexed with hyz, po4
12. Domain for 3bel:
  - Domain d3bela_: 3bel A: [208629]
    automated match to d3gt8b_
    complexed with po4, pox
13. Domains for 3gt8:
  1. Domain d3gt8a_: 3gt8 A: [176980]
    automated match to d1m14a_
    complexed with anp, mg
  2. Domain d3gt8b_: 3gt8 B: [176981]
    automated match to d1m14a_
    complexed with anp, mg
  3. Domain d3gt8c_: 3gt8 C: [176982]
    automated match to d1m14a_
    complexed with anp, mg
  4. Domain d3gt8d_: 3gt8 D: [176983]
    automated match to d1m14a_
    complexed with anp, mg
14. Domains for 3ika:
  1. Domain d3ikaa_: 3ika A: [178367]
    automated match to d1m14a_
    complexed with 0un; mutant
  2. Domain d3ikab_: 3ika B: [178368]
    automated match to d1m14a_
    complexed with 0un; mutant
15. Domain for 3poz:
  - Domain d3poza_: 3poz A: [183915]
    automated match to d1m14a_
    complexed with 03p, so4
16. Domain for 3ug1:
  - Domain d3ug1a_: 3ug1 A: [195858]
    automated match to d2gs6a_
    complexed with mes
17. Domain for 3ug2:
  - Domain d3ug2a_: 3ug2 A: [195859]
    automated match to d2gs6a_
    complexed with ire, mes
18. Domain for 3vjn:
  - Domain d3vjna_: 3vjn A: [195851]
    automated match to d2gs6a_
    complexed with anp
19. Domain for 3vjo:
  - Domain d3vjoa_: 3vjo A: [195853]
    automated match to d2gs6a_
    complexed with anp
20. Domain for 3w2o:
  - Domain d3w2oa_: 3w2o A: [194105]
    automated match to d1m14a_
    complexed with 03p; mutant
21. Domain for 3w2p:
  - Domain d3w2pa_: 3w2p A: [194104]
    automated match to d1m14a_
    complexed with w2p; mutant
22. Domain for 3w2q:
  - Domain d3w2qa_: 3w2q A: [233922]
    automated match to d3w2oa_
    complexed with hki, mes; mutant
23. Domain for 3w2r:
  - Domain d3w2ra_: 3w2r A: [233923]
    automated match to d3w2oa_
    complexed with edo, w2r; mutant
24. Domain for 3w2s:
  - Domain d3w2sa_: 3w2s A: [218196]
    automated match to d2gs6a_
    complexed with so4, w2r
25. Domain for 3w32:
  - Domain d3w32a_: 3w32 A: [193901]
    automated match to d2gs6a_
    complexed with so4, w32
26. Domain for 3w33:
  - Domain d3w33a_: 3w33 A: [193900]
    automated match to d2gs6a_
    complexed with so4, w19
27. Domain for 4hjo:
  - Domain d4hjoa_: 4hjo A: [194321]
    automated match to d1m14a_
    complexed with aq4
28. Domain for 4i22:
  - Domain d4i22a_: 4i22 A: [194134]
    automated match to d1m14a_
    complexed with ire, so4; mutant
29. Domain for 4i23:
  - Domain d4i23a_: 4i23 A: [194125]
    automated match to d1m14a_
    complexed with 1c9
30. Domains for 4i24:
  1. Domain d4i24a_: 4i24 A: [193289]
    automated match to d1m14a_
    complexed with 1c9
  2. Domain d4i24b_: 4i24 B: [234764]
    automated match to d4i24a_
    complexed with 1c9
31. Domain for 4jq7:
  - Domain d4jq7a_: 4jq7 A: [223939]
    automated match to d4jq8a_
    complexed with kjq
32. Domain for 4jq8:
  - Domain d4jq8a_: 4jq8 A: [197414]
    automated match to d1m14a_
    complexed with kj8
33. Domain for 4jr3:
  - Domain d4jr3a_: 4jr3 A: [223948]
    automated match to d4jq8a_
    complexed with kjr
34. Domain for 4jrv:
  - Domain d4jrva_: 4jrv A: [223973]
    automated match to d4jq8a_
    complexed with kjv
35. Domain for 4li5:
  - Domain d4li5a_: 4li5 A: [224685]
    automated match to d2eb2a_
    complexed with 1wy, na
36. Domain for 4lqm:
  - Domain d4lqma_: 4lqm A: [236055]
    automated match to d3ikaa_
    complexed with cl, djk
37. Domain for 4r5s:
  - Domain d4r5sa_: 4r5s A: [260963]
    automated match to d3ikaa_
    complexed with fi3
38. Domains for 4riw:
  1. Domain d4riwb_: 4riw B: [261970]
    Other proteins in same PDB: d4riwa_, d4riwc_
    automated match to d3ikaa_
    complexed with adp, anp, mg
  2. Domain d4riwd_: 4riw D: [261572]
    Other proteins in same PDB: d4riwa_, d4riwc_
    automated match to d3ikaa_
    complexed with adp, anp, mg
39. Domains for 4rix:
  1. Domain d4rixb_: 4rix B: [261968]
    Other proteins in same PDB: d4rixa_, d4rixc_
    automated match to d3ikaa_
    complexed with adp, anp, mg; mutant
  2. Domain d4rixd_: 4rix D: [261969]
    Other proteins in same PDB: d4rixa_, d4rixc_
    automated match to d3ikaa_
    complexed with adp, anp, mg; mutant
40. Domains for 4riy:
  1. Domain d4riyb_: 4riy B: [261570]
    Other proteins in same PDB: d4riya_, d4riyc_
    automated match to d3ikaa_
    complexed with adp, anp, mg; mutant
  2. Domain d4riyd_: 4riy D: [261571]
    Other proteins in same PDB: d4riya_, d4riyc_
    automated match to d3ikaa_
    complexed with adp, anp, mg; mutant
41. Domain for 4rj5:
  - Domain d4rj5a_: 4rj5 A: [261573]
    automated match to d3ikaa_
    complexed with 3qy
42. Domain for 4rj8:
  - Domain d4rj8a_: 4rj8 A: [261275]
    automated match to d3ikaa_
    complexed with 3qs, so4
43. Domain for 4wkq:
  - Domain d4wkqa_: 4wkq A: [260857]
    automated match to d4li5a_
    complexed with ire, mes, na
44. Domain for 4wrg:
  - Domain d4wrga_: 4wrg A: [260864]
    automated match to d4li5a_
    complexed with mes, na
45. Domain for 4zau:
  - Domain d4zaua_: 4zau A: [279404]
    automated match to d4li5a_
    complexed with yy3
46. Domain for 5c8k:
  - Domain d5c8ka_: 5c8k A: [278538]
    automated match to d4li5a_
    complexed with 4yv; mutant
47. Domain for 5c8m:
  - Domain d5c8ma_: 5c8m A: [278541]
    automated match to d4li5a_
    complexed with 4yw; mutant
48. Domain for 5c8n:
  - Domain d5c8na_: 5c8n A: [278539]
    automated match to d4li5a_
    complexed with 4yx, so4; mutant
49. Domain for 5cal:
  - Domain d5cala_: 5cal A: [278540]
    automated match to d4li5a_
    complexed with 4z8; mutant
50. Domain for 5can:
  - Domain d5cana_: 5can A: [278550]
    automated match to d4li5a_
    complexed with 4zb, so4; mutant
51. Domain for 5cao:
  - Domain d5caoa_: 5cao A: [278542]
    automated match to d4li5a_
    complexed with 4zg; mutant
52. Domain for 5cap:
  - Domain d5capa_: 5cap A: [278544]
    automated match to d4li5a_
    complexed with 4zh, so4; mutant
53. Domain for 5caq:
  - Domain d5caqa_: 5caq A: [278549]
    automated match to d4li5a_
    complexed with 4zj, so4; mutant
54. Domain for 5cas:
  - Domain d5casa_: 5cas A: [278543]
    automated match to d4li5a_
    complexed with 4zq, so4; mutant
55. Domain for 5cau:
  - Domain d5caua_: 5cau A: [278545]
    automated match to d4li5a_
    complexed with 4zr, so4; mutant
56. Domain for 5cav:
  - Domain d5cava_: 5cav A: [278551]
    automated match to d4wkqa_
    complexed with 4zq
57. Domains for 5cnn:
  1. Domain d5cnna_: 5cnn A: [275382]
    automated match to d4li5a_
    complexed with anp, mg; mutant
  2. Domain d5cnnb_: 5cnn B: [275375]
    automated match to d4li5a_
    complexed with anp, mg; mutant
58. Domains for 5cno:
  1. Domain d5cnoa_: 5cno A: [275380]
    automated match to d4li5a_
    complexed with anp, mg; mutant
  2. Domain d5cnob_: 5cno B: [275378]
    automated match to d4li5a_
    complexed with anp, mg; mutant
  3. Domain d5cnox_: 5cno X: [275379]
    automated match to d4li5a_
    complexed with anp, mg; mutant
59. Domain for 5edp:
  - Domain d5edpa_: 5edp A: [279749]
    automated match to d4li5a_
60. Domain for 5edq:
  - Domain d5edqa_: 5edq A: [279747]
    automated match to d4li5a_
    complexed with 5n3
61. Domain for 5edr:
  - Domain d5edra_: 5edr A: [279748]
    automated match to d4li5a_
    complexed with 5n4
62. Domain for 5em5:
  - Domain d5em5a_: 5em5 A: [280161]
    automated match to d4li5a_
    complexed with 5q2; mutant
63. Domain for 5em6:
  - Domain d5em6a_: 5em6 A: [280157]
    automated match to d4li5a_
    complexed with 5q3, so4; mutant
64. Domain for 5em7:
  - Domain d5em7a_: 5em7 A: [280160]
    automated match to d4li5a_
    complexed with 5q4, so4; mutant
65. Domain for 5em8:
  - Domain d5em8a_: 5em8 A: [280163]
    automated match to d1m14a_
    complexed with 5q4

More info for Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.7: Protein kinases, catalytic subunit

Timeline for Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.7: Protein kinases, catalytic subunit:

Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.7: Protein kinases, catalytic subunit first appeared in SCOP 1.63, called Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.2: Tyrosine kinase
Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.7: Protein kinases, catalytic subunit appears in SCOPe 2.04
Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.7: Protein kinases, catalytic subunit appears in SCOPe 2.06
Protein EGF receptor tyrosine kinase, Erbb-1 from d.144.1.7: Protein kinases, catalytic subunit appears in the current release, SCOPe 2.08