Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1671838Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments

Proteins:

  1. 16718393-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. 1671868Abelsone tyrosine kinase (abl) [56166] (2 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. 1671869Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [56167] (7 PDB entries)
  3. 1671895Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. 1671973B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. 1671979Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 1671983c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. 1672015c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. 1672024c-src tyrosine kinase [56155] (2 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. 1672025Species Chicken (Gallus gallus) [TaxId:9031] [56157] (35 PDB entries)
    2. 1672095Species Human (Homo sapiens) [TaxId:9606] [56156] (12 PDB entries)
  10. 1672113Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. 1672116cAMP-dependent PK, catalytic subunit [56116] (5 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. 1672117Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. 1672119Species Cow (Bos taurus) [TaxId:9913] [56118] (39 PDB entries)
      Uniprot P00517
    3. 1672161Species Mouse (Mus musculus) [TaxId:10090] [56119] (26 PDB entries)
    4. 1672191Species Norway rat (Rattus norvegicus) [TaxId:10116] [256101] (1 PDB entry)
    5. 1672193Species Pig (Sus scrofa) [TaxId:9823] [56117] (9 PDB entries)
  12. 1672206Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. 1672218Casein kinase-1, CK1 [56139] (4 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. 1672219Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. 1672224Species Human (Homo sapiens) [TaxId:9606] [224941] (8 PDB entries)
    3. 1672246Species Mouse (Mus musculus) [TaxId:10090] [197326] (1 PDB entry)
    4. 1672249Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. 1672254Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. 1672314Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  16. 1672320Cell division protein kinase 9, CDK9 [160810] (1 species)
  17. 1672328Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. 1672329Species Human (Homo sapiens) [TaxId:9606] [88856] (340 PDB entries)
      Uniprot P24941
    2. 1672758Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
  18. 1672767Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  19. 1672779Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  20. 1672796Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  21. 1672805Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  22. 1672829Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  23. 1672833EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  24. 1672888epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  25. 1672892ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  26. 1672896Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  27. 1672938Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  28. 1672977Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  29. 1672980Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. 1672981Species Chicken (Gallus gallus) [TaxId:9031] [187336] (2 PDB entries)
    2. 1672984Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)
  30. 1673007G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  31. 1673018gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  32. 1673023Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  33. 1673092Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  34. 1673130Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  35. 1673174Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  36. 1673196Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  37. 1673245Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  38. 1673283MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  39. 1673334MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 1673335Species Human (Homo sapiens) [TaxId:9606] [56135] (3 PDB entries)
    2. 1673340Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (19 PDB entries)
  40. 1673363MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 1673364Species Human (Homo sapiens) [TaxId:9606] [56130] (162 PDB entries)
    2. 1673544Species Mouse (Mus musculus) [TaxId:10090] [56131] (22 PDB entries)
  41. 1673567MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  42. 1673571Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  43. 1673575Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  44. 1673578Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  45. 1673587pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  46. 1673603Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  47. 1673625Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase
  48. 1673628Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. 1673629Species Human (Homo sapiens) [TaxId:9606] [75559] (41 PDB entries)
    2. 1673685Species Maize (Zea mays) [TaxId:4577] [56143] (32 PDB entries)
    3. 1673723Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)
  49. 1673728Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase
  50. 1673733Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  51. 1673806Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  52. 1673809Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase
  53. 1673817Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)
  54. 1673820Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  55. 1673831STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  56. 1673837Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  57. 1673841Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  58. 1673845Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. 1673846Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. 1673848Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  59. 1673851Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  60. 1673870Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  61. 1673918Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  62. 1673950Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  63. 1673953Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  64. 1673984automated matches [190091] (13 species)
    not a true protein
    1. 1673985Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (9 PDB entries)
    2. 1674002Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)
    3. 1674005Species Chicken (Gallus gallus) [TaxId:9031] [187329] (6 PDB entries)
    4. 1674012Species Cow (Bos taurus) [TaxId:9913] [187007] (27 PDB entries)
    5. 1674050Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)
    6. 1674053Species Drosophila melanogaster [TaxId:7227] [258686] (1 PDB entry)
    7. 1674055Species Human (Homo sapiens) [TaxId:9606] [188447] (490 PDB entries)
    8. 1674739Species Maize (Zea mays) [TaxId:4577] [195345] (1 PDB entry)
    9. 1674741Species Mouse (Mus musculus) [TaxId:10090] [187169] (34 PDB entries)
    10. 1674797Species Mycobacterium tuberculosis [TaxId:1773] [225570] (2 PDB entries)
    11. 1674801Species Mycobacterium tuberculosis [TaxId:419947] [226040] (7 PDB entries)
    12. 1674812Species Norway rat (Rattus norvegicus) [TaxId:10116] [226719] (1 PDB entry)
    13. 1674814Species Oryza sativa [TaxId:39947] [256089] (1 PDB entry)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: