Lineage for Family c.36.1.6: TK-like Pyr module

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108389Family c.36.1.6: TK-like Pyr module [88735] (2 protein domains)
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Protein Domains:

  1. 2108390Pyruvate dehydrogenase E1 component, Pyr module [88739] (1 species)
    E1A and E1B fused together in a single-chain protein
  2. 2108404Transketolase (TK), Pyr module [88736] (4 species)
    1. 2108405Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88737] (7 PDB entries)
    2. Species Escherichia coli [TaxId:562] [89650] (1 PDB entry)
    3. 2108423Species Leishmania mexicana mexicana [TaxId:44270] [117521] (1 PDB entry)
      Uniprot Q8MPM3
    4. 2108426Species Maize (Zea mays) [TaxId:4577] [88738] (1 PDB entry)

More info for Family c.36.1.6: TK-like Pyr module

Timeline for Family c.36.1.6: TK-like Pyr module: