![]() | Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
![]() | Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
![]() | Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) ![]() there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
![]() | Family c.36.1.6: TK-like Pyr module [88735] (2 proteins) different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain |
![]() | Pyruvate dehydrogenase E1 component, Pyr module [88739] (1 species) E1A and E1B fused together in a single-chain protein |
![]() | Species Escherichia coli [TaxId:562] [88740] (6 PDB entries) |
![]() | Transketolase (TK), Pyr module [88736] (4 species) |
![]() | Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88737] (7 PDB entries) |
Species Escherichia coli [TaxId:562] [89650] (1 PDB entry) |
![]() | Species Leishmania mexicana mexicana [TaxId:44270] [117521] (1 PDB entry) Uniprot Q8MPM3 |
![]() | Species Maize (Zea mays) [TaxId:4577] [88738] (1 PDB entry) |
Timeline for Family c.36.1.6: TK-like Pyr module: