SCOPe 2.05: Protein: Pyruvate decarboxylase

Lineage for Protein: Pyruvate decarboxylase

Root: SCOPe 2.05
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
automatically mapped to Pfam PF02776

Protein Pyruvate decarboxylase [88725] (3 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88727] (2 PDB entries)
1. Domains for 1pvd:
  1. Domain d1pvda2: 1pvd A:2-181 [31777]
    Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
    complexed with mg, tpp
  2. Domain d1pvdb2: 1pvd B:2-181 [31779]
    Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
    complexed with mg, tpp
2. Domains for 1qpb:
  1. Domain d1qpba2: 1qpb A:2-181 [31781]
    Other proteins in same PDB: d1qpba1, d1qpba3, d1qpbb1, d1qpbb3
    complexed with mg, pym, tpp
  2. Domain d1qpbb2: 1qpb B:2-181 [31783]
    Other proteins in same PDB: d1qpba1, d1qpba3, d1qpbb1, d1qpbb3
    complexed with mg, pym, tpp
Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [88726] (1 PDB entry)
- Domains for 1pyd:
  1. Domain d1pyda2: 1pyd A:2-181 [31773]
    Other proteins in same PDB: d1pyda1, d1pyda3, d1pydb1, d1pydb3
    complexed with mg, tdp
  2. Domain d1pydb2: 1pyd B:2-181 [31775]
    Other proteins in same PDB: d1pyda1, d1pyda3, d1pydb1, d1pydb3
    complexed with mg, tdp
Zymomonas mobilis [TaxId:542] [88728] (1 PDB entry)
- Domains for 1zpd:
  1. Domain d1zpda2: 1zpd A:2-187 [31785]
    Other proteins in same PDB: d1zpda1, d1zpda3, d1zpdb1, d1zpdb3, d1zpde1, d1zpde3, d1zpdf1, d1zpdf3
    complexed with cit, dpx, mg
  2. Domain d1zpdb2: 1zpd B:2-187 [31787]
    Other proteins in same PDB: d1zpda1, d1zpda3, d1zpdb1, d1zpdb3, d1zpde1, d1zpde3, d1zpdf1, d1zpdf3
    complexed with cit, dpx, mg
  3. Domain d1zpde2: 1zpd E:2-187 [31789]
    Other proteins in same PDB: d1zpda1, d1zpda3, d1zpdb1, d1zpdb3, d1zpde1, d1zpde3, d1zpdf1, d1zpdf3
    complexed with cit, dpx, mg
  4. Domain d1zpdf2: 1zpd F:2-187 [31791]
    Other proteins in same PDB: d1zpda1, d1zpda3, d1zpdb1, d1zpdb3, d1zpde1, d1zpde3, d1zpdf1, d1zpdf3
    complexed with cit, dpx, mg

More info for Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.04
Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.06
Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in the current release, SCOPe 2.08