Lineage for Protein: Pyruvate decarboxylase

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108260Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 protein domains)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
    automatically mapped to Pfam PF02776
  6. 2108366Protein Pyruvate decarboxylase [88725] (3 species)

Species:

  1. 2108367Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88727] (2 PDB entries)
    1. Domains for 1pvd:
      1. 2108368Domain d1pvda2: 1pvd A:2-181 [31777]
        Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
        complexed with mg, tpp
      2. 2108369Domain d1pvdb2: 1pvd B:2-181 [31779]
        Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
        complexed with mg, tpp
    2. Domains for 1qpb:
      1. 2108370Domain d1qpba2: 1qpb A:2-181 [31781]
        Other proteins in same PDB: d1qpba1, d1qpba3, d1qpbb1, d1qpbb3
        complexed with mg, pym, tpp
      2. 2108371Domain d1qpbb2: 1qpb B:2-181 [31783]
        Other proteins in same PDB: d1qpba1, d1qpba3, d1qpbb1, d1qpbb3
        complexed with mg, pym, tpp
  2. 2108372Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [88726] (1 PDB entry)
  3. 2108375Zymomonas mobilis [TaxId:542] [88728] (1 PDB entry)

More info for Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module: