SCOPe 2.08: Domain d1kfxl3: 1kfx L:2-355

Lineage for d1kfxl3 (1kfx L:2-355)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
   automatically mapped to Pfam PF00648

6. Protein Calpain large subunit, catalytic domain (domain II) [54041] (6 species)
   includes the N-terminal 'sequence' domain I

7. Species Human (Homo sapiens), M-type [TaxId:9606] [54042] (2 PDB entries)

8. Domain d1kfxl3: 1kfx L:2-355 [68577]
   Other proteins in same PDB: d1kfxl1, d1kfxl2, d1kfxs_

Details for d1kfxl3

PDB Entry: 1kfx, 3.15 Å

PDB Description: Crystal Structure of Human m-Calpain Form I

PDB Compounds: (L:) m-calpain large subunit

SCOPe Domain Sequences for d1kfxl3:

Sequence, based on SEQRES records:

>d1kfxl3 d.3.1.3 (L:2-355) Calpain large subunit, catalytic domain (domain II) {Human (Homo sapiens), M-type [TaxId: 9606]}
agiaaklakdreaaeglgsheraikylnqdyealrnecleagtlfqdpsfpaipsalgfk
elgpyssktrgmrwkrpteicadpqfiiggatrtdicqgalgdcwllaaiasltlneeil
arvvplnqsfqenyagifhfqfwqygewvevvvddrlptkdgellfvhsaegsefwsall
ekayakingcyealsggattegfedftggiaewyelkkpppnlfkiiqkalqkgsllgcs
iditsaadseaitfqklvkghaysvtgaeevesngslqklirirnpwgevewtgrwndnc
pswntidpeererltrrhedgefwmsfsdflrhysrleicnltpdtltsdtykk

Sequence, based on observed residues (ATOM records):

>d1kfxl3 d.3.1.3 (L:2-355) Calpain large subunit, catalytic domain (domain II) {Human (Homo sapiens), M-type [TaxId: 9606]}
agiaaklakdreaaeglgsheraikylnqdyealrnecleagtlfqdpsfpaipsalgfk
elgpyssktrgmrwkrpteicadpqfiiggatrtdicqgalgdcwllaaiasltlneeil
arvvplnqsfqenyagifhfqfwqygewvevvvddrlptkdgellfvhsaegsefwsall
ekayakingcyealsggattegfedftggiaewyelkkpppnlfkiiqkalqkgsllgcs
idkghaysvtgaeevesngslqklirirnpwgevewtgrwmsfsdflrhysrleicnltp
dtltsdtykk

Timeline for d1kfxl3:

• d1kfxl3 first appeared in SCOP 1.59
  
• d1kfxl3 appears in SCOPe 2.07