SCOP 1.63: Domain d1g5sa_: 1g5s A:

Lineage for d1g5sa_ (1g5s A:)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.1: Serine/threonin kinases [56113] (21 proteins)

6. Protein Cyclin-dependent PK (CDK, different isozymes) [56114] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56115] (47 PDB entries)

8. Domain d1g5sa_: 1g5s A: [65167]
   complexed with i17

Details for d1g5sa_

PDB Entry: 1g5s, 2.61 Å

PDB Description: crystal structure of human cyclin dependent kinase 2 (cdk2) in complex with the inhibitor h717

SCOP Domain Sequences for d1g5sa_:

Sequence, based on SEQRES records:

>d1g5sa_ d.144.1.1 (A:) Cyclin-dependent PK (CDK, different isozymes) {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d1g5sa_ d.144.1.1 (A:) Cyclin-dependent PK (CDK, different isozymes) {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirstaireisllkelnhpnivklldv
ihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlk
pqnllintegaikladfglvvtlwyrapeillgckyystavdiwslgcifaemvtrralf
pgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppldedgrsll
sqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d1g5sa_:

• d1g5sa_ first appeared in SCOP 1.59
  
• d1g5sa_ appears in SCOP 1.61
  
• d1g5sa_ appears in SCOP 1.65
  
• d1g5sa_ appears in the current release, SCOPe 2.08