SCOP 1.67: Domain d1e92a_: 1e92 A:

Lineage for d1e92a_ (1e92 A:)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (40 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

7. Species Leishmania major [TaxId:5664] [63926] (2 PDB entries)

8. Domain d1e92a_: 1e92 A: [64798]

Details for d1e92a_

PDB Entry: 1e92, 2.2 Å

PDB Description: pteridine reductase 1 from leishmania major complexed with nadp+ and dihydrobiopterin

SCOP Domain Sequences for d1e92a_:

Sequence, based on SEQRES records:

>d1e92a_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Leishmania major}
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrndedg
hepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtn
qpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrskv
plyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d1e92a_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Leishmania major}
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrndgdreametat
adlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakga
legltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdv
viflcsskakyitgtcvkvdggysltra

Timeline for d1e92a_:

• d1e92a_ first appeared in SCOP 1.59
  
• d1e92a_ appears in SCOP 1.65
  
• d1e92a_ appears in SCOP 1.69
  
• d1e92a_ appears in the current release, SCOPe 2.08