Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOP 1.67
  2. 383641Class c: Alpha and beta proteins (a/b) [51349] (130 folds)
  3. 387036Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 387037Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families) (S)
  5. 387288Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (40 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

  1. 387289(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 3872951,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  3. 3872981,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  4. 3873103-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  5. 3873203-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  6. 3873263beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  7. 3873327-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  8. 387340ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  9. 387352beta-keto acyl carrier protein reductase [51788] (3 species)
    1. 387353Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 387368Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (1 PDB entry)
    3. 387370Species Thermotoga maritima [TaxId:243274] [102150] (1 PDB entry)
      TM1169
  10. 387375Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  11. 387382Carbonyl reductase [51765] (2 species)
    1. 387383Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 387386Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  12. 387391Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (1 species)
  13. 387394CDP-glucose-4,6-dehydratase [102136] (1 species)
  14. 387400CDP-tyvelose-2-epimerase [102138] (1 species)
  15. 387406Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  16. 387409Dihydropteridin reductase (pteridine reductase) [51769] (6 species)
    1. 387410Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 387412Species Leishmania major [TaxId:5664] [63926] (2 PDB entries)
    3. 387419Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 387424Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 387427Species Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 387433Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  17. 387442Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 387443Species Fruit fly (Drosophila lebanonensis) [51783] (5 PDB entries)
    2. 387453Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  18. 387456dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)
  19. 387462dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 387463Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 387466Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 387471Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 387484Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  20. 387487Enoyl-ACP reductase [51791] (5 species)
    1. 387488Species Escherichia coli [TaxId:562] [51794] (12 PDB entries)
    2. 387523Species Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    3. 387532Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (4 PDB entries)
    4. 387541Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (6 PDB entries)
    5. 387559Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
  21. 387565GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  22. 387575GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 387576Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 387578Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
    3. 387583Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 387588Species Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  23. 387595Glucose dehydrogenase [51784] (1 species)
  24. 387613Glucose dehydrogenase (5l265) [102155] (1 species)
  25. 387616Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  26. 387628Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  27. 387650Levodione reductase [89523] (1 species)
  28. 387660Mannitol dehydrogenase [63927] (1 species)
  29. 387674meso-2,3-butanediol dehydrogenase [51786] (1 species)
  30. 387684Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  31. 387691Phenylcoumaran benzylic ether reductase [102140] (1 species)
  32. 387695Pinoresinol-lariciresinol reductase [102142] (1 species)
  33. 387701Putative oxidoreductase Rv2002 [82292] (1 species)
  34. 387713R-specific alcohol dehydrogenase [89521] (1 species)
  35. 387716Sepiapterin reductase [51767] (1 species)
  36. 387721Sorbitol dehydrogenase [102148] (1 species)
  37. 387725Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  38. 387731Tropinone reductase [51795] (2 species)
    1. 387732Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 387735Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
  39. 387743Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 387744Species Human (Homo sapiens) [TaxId:9606] [102152] (1 PDB entry)
    2. 387746Species Rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 387759Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  40. 387762Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (3 species)
    1. 387763Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    2. 387782Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    3. 387796Species Trypanosoma brucei [TaxId:5691] [89519] (1 PDB entry)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: