SCOP 1.67: Family c.2.1.2: Tyrosine-dependent oxidoreductases

Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (40 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

1. (3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
   peroxisomal multifunctional enzyme type 2
   segment swapping involving a C-terminal extension to the family fold

   • Species Rat (Rattus norvegicus) [TaxId:10116] [82295] (1 PDB entry)

2. 1,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)

   • Species Rice blast fungus (Magnaporthe grisea) [TaxId:148305] [63930] (1 PDB entry)

3. 1,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)

   • Species Rice blast fungus (Magnaporthe grisea) [TaxId:148305] [51799] (4 PDB entries)

4. 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)

   • Species Streptomyces hydrogenans [TaxId:1905] [51777] (2 PDB entries)

5. 3-alpha-hydroxysteroid dehydrogenase [51778] (1 species)

   • Species Comamonas testosteroni [TaxId:285] [51779] (2 PDB entries)

6. 3beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)

   • Species Comamonas testosteroni [TaxId:285] [82291] (1 PDB entry)

7. 7-alpha-hydroxysteroid dehydrogenase [51774] (1 species)

   • Species Escherichia coli [TaxId:562] [51775] (3 PDB entries)

8. ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)

   • Species Escherichia coli [TaxId:562] [51762] (1 PDB entry)

9. beta-keto acyl carrier protein reductase [51788] (3 species)

   1. Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)

   2. Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (1 PDB entry)

   3. Species Thermotoga maritima [TaxId:243274] [102150] (1 PDB entry)
      TM1169

10. Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad

    • Species Human (Homo sapiens) [TaxId:9606] [63932] (5 PDB entries)

11. Carbonyl reductase [51765] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
       dicarbonyl/L-xylulose reductase

    2. Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)

12. Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (1 species)

    • Species Pig (Sus scrofa) [TaxId:9823] [63936] (1 PDB entry)

13. CDP-glucose-4,6-dehydratase [102136] (1 species)

    • Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)

14. CDP-tyvelose-2-epimerase [102138] (1 species)

    • Species Salmonella typhi [TaxId:90370] [102139] (1 PDB entry)

15. Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)

    • Species Pseudomonas sp., lb400 [TaxId:306] [51781] (1 PDB entry)

16. Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)

    2. Species Leishmania major [TaxId:5664] [63926] (2 PDB entries)

    3. Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)

    4. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)

    5. Species Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)

    6. Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)

17. Drosophila alcohol dehydrogenase [51782] (2 species)

    1. Species Fruit fly (Drosophila lebanonensis) [51783] (5 PDB entries)

    2. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)

18. dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)

    • Species Salmonella enterica serovar typhimurium [TaxId:90371] [75103] (4 PDB entries)

19. dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)

    1. Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)

    2. Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)

    3. Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)

    4. Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)

20. Enoyl-ACP reductase [51791] (5 species)

    1. Species Escherichia coli [TaxId:562] [51794] (12 PDB entries)

    2. Species Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)

    3. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (4 PDB entries)

    4. Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (6 PDB entries)

    5. Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)

21. GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)

    • Species Escherichia coli [TaxId:562] [51758] (8 PDB entries)

22. GDP-mannose 4,6-dehydratase [51759] (4 species)

    1. Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)

    3. Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)

    4. Species Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)

23. Glucose dehydrogenase [51784] (1 species)

    • Species Bacillus megaterium [TaxId:1404] [51785] (4 PDB entries)

24. Glucose dehydrogenase (5l265) [102155] (1 species)

    • Species Nematode (Caenorhabditis elegans) [TaxId:6239] [102156] (1 PDB entry)

25. Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site

    • Species Agrobacterium tumefaciens [TaxId:358] [102154] (3 PDB entries)

26. Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [51773] (13 PDB entries)

27. Levodione reductase [89523] (1 species)

    • Species Corynebacterium aquaticum [TaxId:144185] [89524] (1 PDB entry)

28. Mannitol dehydrogenase [63927] (1 species)

    • Species Mushroom (Agaricus bisporus) [TaxId:5341] [63928] (1 PDB entry)

29. meso-2,3-butanediol dehydrogenase [51786] (1 species)

    • Species Klebsiella pneumoniae [TaxId:573] [51787] (1 PDB entry)

30. Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function

    • Species Aspergillus nidulans [TaxId:162425] [69408] (4 PDB entries)

31. Phenylcoumaran benzylic ether reductase [102140] (1 species)

    • Species Loblolly pine (Pinus taeda) [TaxId:3352] [102141] (1 PDB entry)

32. Pinoresinol-lariciresinol reductase [102142] (1 species)

    • Species Giant arborvitae (Thuja plicata) [TaxId:3316] [102143] (1 PDB entry)

33. Putative oxidoreductase Rv2002 [82292] (1 species)

    • Species Mycobacterium tuberculosis [TaxId:1773] [82293] (3 PDB entries)

34. R-specific alcohol dehydrogenase [89521] (1 species)

    • Species Lactobacillus brevis [89522] (1 PDB entry)

35. Sepiapterin reductase [51767] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)

36. Sorbitol dehydrogenase [102148] (1 species)

    • Species Rhodobacter sphaeroides [TaxId:1063] [102149] (1 PDB entry)

37. Sulfolipid biosynthesis protein SQD1 [51763] (1 species)

    • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [51764] (4 PDB entries)

38. Tropinone reductase [51795] (2 species)

    1. Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)

    2. Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)

39. Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [102152] (1 PDB entry)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)

    3. Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)

40. Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (3 species)

    1. Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)

    3. Species Trypanosoma brucei [TaxId:5691] [89519] (1 PDB entry)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases:

• Family c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
  
• Family c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.65
  
• Family c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.69
  
• Family c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08