Class c: Alpha and beta proteins (a/b) [51349] (130 folds) |
Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families) |
Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (40 proteins) also known as short-chain dehydrogenases and SDR family parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 |
Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species) |
Species Leishmania major [TaxId:5664] [63926] (2 PDB entries) |
Domain d1e7wa_: 1e7w A: [59373] |
Domain d1e7wb_: 1e7w B: [59374] complexed with edo, mtx, ndp |
Domain d1e92a_: 1e92 A: [64798] |
Domain d1e92b_: 1e92 B: [64799] |
Domain d1e92c_: 1e92 C: [64800] |
Domain d1e92d_: 1e92 D: [64801] complexed with edo, hbi, nap |
Timeline for Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase):