SCOP 1.63: Domain d1jsva_: 1jsv A:

Lineage for d1jsva_ (1jsv A:)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.1: Serine/threonin kinases [56113] (21 proteins)

6. Protein Cyclin-dependent PK (CDK, different isozymes) [56114] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56115] (47 PDB entries)

8. Domain d1jsva_: 1jsv A: [63278]
   complexed with u55

Details for d1jsva_

PDB Entry: 1jsv, 1.96 Å

PDB Description: the structure of cyclin-dependent kinase 2 (cdk2) in complex with 4- [(6-amino-4-pyrimidinyl)amino]benzenesulfonamide

SCOP Domain Sequences for d1jsva_:

Sequence, based on SEQRES records:

>d1jsva_ d.144.1.1 (A:) Cyclin-dependent PK (CDK, different isozymes) {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d1jsva_ d.144.1.1 (A:) Cyclin-dependent PK (CDK, different isozymes) {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirtaireisllkelnhpnivklldvi
htenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlkp
qnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiwslg
cifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfsk
vvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d1jsva_:

• d1jsva_ first appeared in SCOP 1.57
  
• d1jsva_ appears in SCOP 1.61
  
• d1jsva_ appears in SCOP 1.65
  
• d1jsva_ appears in the current release, SCOPe 2.08