SCOP 1.69: Domain d1f45b_: 1f45 B:

Lineage for d1f45b_ (1f45 B:)

1. Root: SCOP 1.69

2. Class a: All alpha proteins [46456] (218 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (9 proteins)

6. Protein Heterodimeric interleukin-12 alpha chain [63530] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63531] (1 PDB entry)

8. Domain d1f45b_: 1f45 B: [59642]
   Other proteins in same PDB: d1f45a1, d1f45a2, d1f45a3

Details for d1f45b_

PDB Entry: 1f45, 2.8 Å

PDB Description: human interleukin-12

SCOP Domain Sequences for d1f45b_:

Sequence, based on SEQRES records:

>d1f45b_ a.26.1.1 (B:) Heterodimeric interleukin-12 alpha chain {Human (Homo sapiens)}
qnllravsnmlqkarqtlefypctseeidheditkdktstveaclpleltknesclnsre
tsfitngsclasrktsfmmalclssiyedlkmyqvefktmnakllmdpkrqifldqnmla
videlmqalnfnsetvpqkssleepdfyktkiklcillhafriravtidrvmsylnas

Sequence, based on observed residues (ATOM records):

>d1f45b_ a.26.1.1 (B:) Heterodimeric interleukin-12 alpha chain {Human (Homo sapiens)}
qnllravsnmlqkarqtlefypcstveaclpleltknesctsfitngssfmmalclssiy
edlkmyqvefktmnakllmdpkrqifldqnmlavidelmqalyktkiklcillhafrira
vtidrvmsylnas

Timeline for d1f45b_:

• d1f45b_ first appeared in SCOP 1.57
  
• d1f45b_ appears in SCOP 1.67
  
• d1f45b_ appears in SCOP 1.71
  
• d1f45b_ appears in the current release, SCOPe 2.08