Lineage for d1f45b_ (1f45 B:)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2705447Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 2705448Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 2705449Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)
  6. 2705486Protein Heterodimeric interleukin-12 alpha chain [63530] (1 species)
  7. 2705487Species Human (Homo sapiens) [TaxId:9606] [63531] (1 PDB entry)
  8. 2705488Domain d1f45b_: 1f45 B: [59642]
    Other proteins in same PDB: d1f45a1, d1f45a2, d1f45a3
    missing some secondary structures that made up less than one-third of the common domain

Details for d1f45b_

PDB Entry: 1f45 (more details), 2.8 Å

PDB Description: human interleukin-12
PDB Compounds: (B:) interleukin-12 alpha chain

SCOPe Domain Sequences for d1f45b_:

Sequence, based on SEQRES records: (download)

>d1f45b_ a.26.1.1 (B:) Heterodimeric interleukin-12 alpha chain {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d1f45b_ a.26.1.1 (B:) Heterodimeric interleukin-12 alpha chain {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1f45b_:

Click to download the PDB-style file with coordinates for d1f45b_.
(The format of our PDB-style files is described here.)

Timeline for d1f45b_: