Lineage for Family a.26.1.1: Long-chain cytokines

  1. Root: SCOP 1.69
  2. 436025Class a: All alpha proteins [46456] (218 folds)
  3. 441656Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 441657Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 441658Family a.26.1.1: Long-chain cytokines [47267] (9 proteins)

Proteins:

  1. 441659Ciliary neurotrophic factor (CNTF) [47280] (1 species)
  2. 441665Granulocyte-colony stimulating factor (G-CSF) [47268] (3 species)
    1. 441666Species Cow (Bos taurus) [TaxId:9913] [47270] (1 PDB entry)
    2. 441668Species Dog (Canis familiaris) [TaxId:9615] [47271] (2 PDB entries)
    3. 441672Species Human (Homo sapiens) [TaxId:9606] [47269] (4 PDB entries)
  3. 441683Growth hormone, somatotropin [47276] (1 species)
  4. 441695Heterodimeric interleukin-12 alpha chain [63530] (1 species)
  5. 441698Interleukin-6 [47272] (2 species)
    1. 441699Species Human (Homo sapiens) [TaxId:9606] [47273] (4 PDB entries)
    2. 441704Species Human herpesvirus 8, Kaposi's sarcoma herpes-virus [TaxId:37296] [63528] (1 PDB entry)
  6. 441706Leptin (obesity protein) [47282] (1 species)
  7. 441709Leukemia inhibitory factor (LIF) [47274] (2 species)
    1. 441710Species Human (Homo sapiens) [TaxId:9606] [63529] (2 PDB entries)
    2. 441714Species Mouse (Mus musculus) [TaxId:10090] [47275] (2 PDB entries)
  8. 441717Oncostatin M [47284] (1 species)
  9. 441720Prolactin (placental lactogen) [47278] (2 species)
    1. 441721Species Human (Homo sapiens) [TaxId:9606] [89035] (1 PDB entry)
    2. 441723Species Sheep (Ovis aries) [TaxId:9940] [47279] (1 PDB entry)

More info for Family a.26.1.1: Long-chain cytokines

Timeline for Family a.26.1.1: Long-chain cytokines: