SCOPe 2.06: Domain d1b68a_: 1b68 A:

Lineage for d1b68a_ (1b68 A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

4. Superfamily a.24.1: Apolipoprotein [47162] (1 family)

5. Family a.24.1.1: Apolipoprotein [47163] (1 protein)
   Can exist in a coiled-coil oligomeric form, see PDB entry 1AV1
   family may also include the five-helical bundle protein Apolipophorin-III

6. Protein Apolipoprotein E [88703] (3 species)

7. Species Human (Homo sapiens), E4 [TaxId:9606] [47169] (3 PDB entries)

8. Domain d1b68a_: 1b68 A: [59076]

Details for d1b68a_

PDB Entry: 1b68, 2 Å

PDB Description: apolipoprotein e4 (apoe4), 22k fragment

PDB Compounds: (A:) apolipoprotein e

SCOPe Domain Sequences for d1b68a_:

Sequence, based on SEQRES records:

>d1b68a_ a.24.1.1 (A:) Apolipoprotein E {Human (Homo sapiens), E4 [TaxId: 9606]}
gqrwelalgrfwdylrwvqtlseqvqeellssqvtqelralmdetmkelkaykseleeql
tpvaeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteelrvrlashlr
klrkrllrdaddlqkrlavy

Sequence, based on observed residues (ATOM records):

>d1b68a_ a.24.1.1 (A:) Apolipoprotein E {Human (Homo sapiens), E4 [TaxId: 9606]}
gqrwelalgrfwdylrwvqtlseqvqeellssqvtqelralmdetmkelkaykseleeql
taeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteelrvrlashlrkl
rkrllrdaddlqkrlavy

Timeline for d1b68a_:

• d1b68a_ first appeared in SCOP 1.57
  
• d1b68a_ appears in SCOPe 2.05
  
• d1b68a_ appears in SCOPe 2.07
  
• d1b68a_ appears in the current release, SCOPe 2.08