SCOPe (Structural Classification of
Proteins — extended) is a database developed
at the Berkeley Lab and UC Berkeley to extend the development and
maintenance of SCOP.
SCOP was conceived at the MRC Laboratory of Molecular Biology, and developed in collaboration with researchers in Berkeley.
Work on SCOP (version 1) concluded in June
2009 with the release of SCOP 1.75.
SCOPe classifies many newer structures
through a combination of automation and manual curation,
and corrects some errors in SCOP,
aiming to have the same accuracy as the hand-curated
incorporates and updates the Astral database.
2017-12-22: SCOPe 2.07-stable is being prepared for release in Feb 2018. The new release features manual classification of domains from many larger structures, including the spliceosome, proteasome, and RNA polymerase I, and many other Pfam families not previously classified in SCOP. We have identified dozens of new superfamilies that will be included in the upcoming release.
New pdb entries were added in a periodic update;
for more info on these updates, see the
We are still without funding, but shutdown has been postponed for a year. More details are here.