SCOPe 2.06: Fold a.24: Four-helical up-and-down bundle

Lineage for Fold a.24: Four-helical up-and-down bundle

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

1. a.24.1: Apolipoprotein [47162] (1 family)

2. a.24.2: Aspartate receptor, ligand-binding domain [47170] (2 families)
   automatically mapped to Pfam PF02203

3. a.24.3: Cytochromes [47175] (3 families)
   Heme-containing proteins

4. a.24.4: Hemerythrin-like [47188] (1 family)

5. a.24.5: TMV-like viral coat proteins [47195] (1 family)
   automatically mapped to Pfam PF00721

6. a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family)
   automatically mapped to Pfam PF08771

7. a.24.8: Proteasome activator [47216] (1 family)

8. a.24.9: alpha-catenin/vinculin-like [47220] (2 families)

9. a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (7 families)
   contains additional, fifth helix at the N-terminus

10. a.24.11: Bacterial GAP domain [47233] (1 family)
    contains extra helices in the loops at one end of the bundle

11. a.24.12: Outer surface protein C (OspC) [63515] (2 families)

12. a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (2 families)

13. a.24.14: FAT domain of focal adhesion kinase [68993] (2 families)

14. a.24.15: FAD-dependent thiol oxidase [69000] (2 families)

15. a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (5 families)

16. a.24.17: Group V grass pollen allergen [81736] (1 family)

17. a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family)
    automatically mapped to Pfam PF05757

18. a.24.19: Flagellar export chaperone FliS [101116] (2 families)
    can form closed, open and helix-swapped bundles

19. a.24.20: Colicin D immunity protein [101125] (1 family)
    automatically mapped to Pfam PF09204

20. a.24.21: RecG, N-terminal domain [69008] (1 family)

21. a.24.22: Nickel-containing superoxide dismutase, NiSOD [109770] (1 family)
    automatically mapped to Pfam PF09055

22. a.24.23: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1 family)
    contains extra alpha+beta subdomain formed by the N- and C-termini.
    automatically mapped to Pfam PF03036

23. a.24.24: Domain from hypothetical 2610208m17rik protein [109779] (1 family)
    automatically mapped to Pfam PF08910

24. a.24.25: TrmE connector domain [116878] (1 family)

25. a.24.26: YppE-like [140415] (1 family)
    flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
    automatically mapped to Pfam PF08807

26. a.24.27: MW0975(SA0943)-like [140423] (1 family)
    open bundle; there is a long groove between helices 1 and 4
    automatically mapped to Pfam PF10368

27. a.24.28: VPS28 C-terminal domain-like [140427] (2 families)

28. a.24.29: TM1646-like [158397] (2 families)
    automatically mapped to Pfam PF03885

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle:

• Fold a.24: Four-helical up-and-down bundle first appeared (with stable ids) in SCOP 1.55
  
• Fold a.24: Four-helical up-and-down bundle appears in SCOPe 2.05
  
• Fold a.24: Four-helical up-and-down bundle appears in SCOPe 2.07
  
• Fold a.24: Four-helical up-and-down bundle appears in the current release, SCOPe 2.08