Lineage for Family g.3.11.1: EGF-type module

  1. Root: SCOPe 2.08
  2. Class g: Small proteins [56992] (100 folds)
  3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. Superfamily g.3.11: EGF/Laminin [57196] (8 families) (S)
  5. Family g.3.11.1: EGF-type module [57197] (23 proteins)

Proteins:

  1. Activated protein c (autoprothrombin IIa) [57208] (1 species)
  2. Betacellulin-2 [75670] (1 species)
  3. Coagulation factor VIIa [57201] (1 species)
  4. Complement C1S component [90143] (1 species)
  5. Complement protease C1R [57229] (1 species)
  6. E-selectin, EGF-domain [57203] (1 species)
  7. Epidermal growth factor, EGF [57215] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [69939] (5 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [57216] (8 PDB entries)
  8. Epiregulin, EGF-domain [103561] (1 species)
  9. Factor IX (IXa) [57198] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [57199] (33 PDB entries)
    2. Species Pig (Sus scrofa) [TaxId:9823] [57200] (2 PDB entries)
  10. Factor X, N-terminal module [57205] (2 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [57207] (5 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [57206] (86 PDB entries)
      Uniprot P00742 127-178
  11. Fibrillin-1 [57227] (1 species)
    duplication: contains 47 EFG-like domains
  12. Heparin-binding epidermal growth factor, HBEGF [57219] (1 species)
    extracellular domain
  13. Heregulin-alpha, EGF-like domain [57223] (1 species)
  14. Low density lipoprotein (LDL) receptor, different EGF domains [64539] (1 species)
  15. Mannose-binding protein associated serine protease 2, MASP2 [90141] (2 species)
    EGF-like domain separates two CUB domains
    1. Species Human (Homo sapiens) [TaxId:9606] [111402] (1 PDB entry)
      Uniprot O00187 17-181
    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [90142] (1 PDB entry)
  16. Neurogenic locus notch homolog protein 1, Notch1 [118243] (1 species)
  17. P-selectin, EGF-domain [57213] (1 species)
  18. Plasminogen activator (tissue-type), t-PA [57231] (1 species)
  19. Plasminogen activator (urokinase-type) [57221] (1 species)
  20. Prostaglandin H2 synthase-1, EGF-like module [57210] (2 species)
    the rest of protein is heme-linked peroxidase, all-alpha fold
    1. Species Mouse (Mus musculus) [TaxId:10090] [57212] (13 PDB entries)
    2. Species Sheep (Ovis aries) [TaxId:9940] [57211] (23 PDB entries)
      Uniprot P05979 32-584
  21. Thrombomodulin, different EGF-like domains [57225] (1 species)
  22. Transforming growth factor alpha [57217] (1 species)
  23. automated matches [190092] (2 species)
    not a true protein
    1. Species Human (Homo sapiens) [TaxId:9606] [187310] (69 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [334131] (3 PDB entries)

More info for Family g.3.11.1: EGF-type module

Timeline for Family g.3.11.1: EGF-type module: