Lineage for Class g: Small proteins

  1. Root: SCOPe 2.06
  2. 2229111Class g: Small proteins [56992] (94 folds)

Folds:

  1. 2229112g.1: Insulin-like [56993] (1 superfamily)
    nearly all-alpha
    can be classified as disulfide-rich
  2. 2229368g.2: Toxic hairpin [57006] (4 superfamilies)
    disulfide crosslinked alpha-helical hairpin
  3. 2229389g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. 2231198g.4: PMP inhibitors [57282] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  5. 2231221g.5: Midkine [57287] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  6. 2231231g.6: Amb V allergen [57295] (1 superfamily)
    disulfide-rich; alpha+beta: 3 antiparallel strands followed by a short alpha helix
  7. 2231239g.7: Snake toxin-like [57301] (1 superfamily)
    disulfide-rich fold: nearly all-beta
  8. 2231603g.8: BPTI-like [57361] (1 superfamily)
    disulfide-rich alpha+beta fold
  9. 2231932g.9: Defensin-like [57391] (1 superfamily)
    Disulfide-rich fold, nearly all-beta
  10. 2232094g.10: Hairpin loop containing domain-like [57413] (1 superfamily)
    alpha+beta fold with two crossing loops
  11. 2232174g.11: Neurotoxin III (ATX III) [57418] (1 superfamily)
    disulfide-rich fold
  12. 2232180g.12: LDL receptor-like module [57423] (1 superfamily)
    disulfide-rich calcium-binding fold
  13. 2232225g.13: Crambin-like [57428] (1 superfamily)
    disulfide-rich alpha+beta fold
  14. 2232295g.14: Kringle-like [57439] (1 superfamily)
    disulfide-rich fold; nearly all-beta
  15. 2232513g.16: Trefoil/Plexin domain-like [57491] (3 superfamilies)
    disulfide-rich fold; common core is alpha+beta with two conserved disulfides
  16. 2232568g.17: Cystine-knot cytokines [57500] (1 superfamily)
    disulfide-rich fold; common core is all-beta
  17. 2232911g.18: Complement control module/SCR domain [57534] (1 superfamily)
    disulfide-rich all-beta fold
  18. 2233192g.19: Crisp domain-like [57545] (1 superfamily)
    disulfide-rich all-alpha fold
  19. 2233234g.20: Blood coagulation inhibitor (disintegrin) [57551] (1 superfamily)
    small disulfide-rich
  20. 2233302g.21: Methylamine dehydrogenase, L chain [57560] (1 superfamily)
    disulfide-rich; nearly all-beta
  21. 2233461g.22: Serine protease inhibitors [57566] (1 superfamily)
    disulfide-rich; nearly all-beta
  22. 2233487g.23: TB module/8-cys domain [57580] (1 superfamily)
    disulfide-rich; alpha+beta
  23. 2233502g.24: TNF receptor-like [57585] (1 superfamily)
    duplication: consists of three similar disulfide-rich domains
  24. 2233669g.25: Heparin-binding domain from vascular endothelial growth factor [57592] (1 superfamily)
    duplication: consists of two similar disulfide-rich domains, alpha+beta
  25. 2233677g.26: Antifungal protein (AGAFP) [57597] (1 superfamily)
    disulfide-rich; all-beta: open barrel, 5 strands; OB-fold-like
  26. 2233683g.27: FnI-like domain [57602] (1 superfamily)
    disulfide-rich, all-beta
  27. 2233747g.28: Thyroglobulin type-1 domain [57609] (1 superfamily)
    disulfide-rich, alpha+beta
  28. 2233773g.29: Type X cellulose binding domain, CBDX [57614] (1 superfamily)
    disulfide-rich, alpha+beta
  29. 2233782g.30: Carboxypeptidase inhibitor [57619] (1 superfamily)
    disulfide-rich, alpha+beta
  30. 2233797g.31: Invertebrate chitin-binding proteins [57624] (1 superfamily)
    disulfide-rich
  31. 2233807g.32: GLA-domain [57629] (1 superfamily)
    Calcium ion-bound
  32. 2233883g.33: Cholecystokinin A receptor, N-domain [57641] (1 superfamily)
    a few helical turns and a disulfide-crosslinked loop
  33. 2233889g.34: HIV-1 VPU cytoplasmic domain [57646] (1 superfamily)
    a few helical turns assembled without a hydrophobic core?
  34. 2233900g.35: HIPIP (high potential iron protein) [57651] (1 superfamily)
    folds around 4Fe-4S cluster
  35. 2233945g.36: Ferredoxin thioredoxin reductase (FTR), catalytic beta chain [57661] (1 superfamily)
    folds around 4Fe-4S cluster
  36. 2233958g.37: beta-beta-alpha zinc fingers [57666] (1 superfamily)
    simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC
  37. 2234342g.38: Zn2/Cys6 DNA-binding domain [57700] (1 superfamily)
    all-alpha dimetal(zinc)-bound fold
  38. 2234384g.39: Glucocorticoid receptor-like (DNA-binding domain) [57715] (1 superfamily)
    alpha+beta metal(zinc)-bound fold
  39. 2234987g.40: Retrovirus zinc finger-like domains [57755] (1 superfamily)
    metal(zinc)-bound fold
  40. 2235033g.41: Rubredoxin-like [57769] (17 superfamilies)
    metal(zinc or iron)-bound fold; sequence contains two CX(n)C motifs, in most cases n = 2
  41. 2236076g.42: Ribosomal protein L36 [57839] (1 superfamily)
    zinc-bound beta-ribbon motif
  42. 2236126g.43: B-box zinc-binding domain [57844] (1 superfamily)
    zinc-bound alpha+beta motif
  43. 2236161g.44: RING/U-box [57849] (1 superfamily)
    dimetal(zinc)-bound alpha+beta motif; structurally diverse
  44. 2236308g.45: ArfGap/RecO-like zinc finger [57862] (1 superfamily)
    zinc-bound alpha+beta motif
  45. 2236328g.46: Metallothionein [57867] (1 superfamily)
    metal(iron)-bound fold
    duplication: consists of clear structural/sequence repeats
  46. 2236372g.47: Zinc domain conserved in yeast copper-regulated transcription factors [57878] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  47. 2236378g.48: Ada DNA repair protein, N-terminal domain (N-Ada 10) [57883] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  48. 2236385g.49: Cysteine-rich domain [57888] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold
  49. 2236446g.50: FYVE/PHD zinc finger [57902] (2 superfamilies)
    dimetal(zinc)-bound alpha+beta fold
  50. 2236596g.51: Zn-binding domains of ADDBP [57916] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  51. 2236615g.52: Inhibitor of apoptosis (IAP) repeat [57923] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  52. 2236831g.53: TAZ domain [57932] (1 superfamily)
    all-alpha fold; Zn-binding sites are in the loops connecting helices
  53. 2236853g.54: DnaJ/Hsp40 cysteine-rich domain [57937] (1 superfamily)
    metal(zinc)-bound extended beta-hairpin fold
  54. 2236862g.55: Cellulose docking domain, dockering [64570] (1 superfamily)
    disulfide-rich, alpha+beta
  55. 2236869g.58: Pheromone ER-23 [69963] (1 superfamily)
    disulfide-rich, all-alpha
  56. 2236875g.59: Zinc-binding domain of translation initiation factor 2 beta [75688] (1 superfamily)
    zinc-bound beta-ribbon motif
  57. 2236887g.60: TSP-1 type 1 repeat [82894] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  58. 2236901g.61: Apical membrane antigen 1 [82909] (1 superfamily)
    disulfide-rich, alpha+beta
  59. 2236909g.62: Cysteine-rich DNA binding domain, (DM domain) [82926] (1 superfamily)
    alpha-helical fold with two Zn-binding sites
  60. 2236915g.63: Mollusk pheromone [90182] (1 superfamily)
    disulfide-rich; all-alpha
  61. 2236922g.64: Somatomedin B domain [90187] (1 superfamily)
    disulfide-rich
  62. 2236933g.65: Notch domain [90192] (1 superfamily)
    disulfide-rich; all-alpha; calcium-binding
  63. 2236939g.66: CCCH zinc finger [90228] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  64. 2236956g.67: Zinc finger domain of DNA polymerase-alpha [90233] (1 superfamily)
    Zn-binding, all-alpha fold
  65. 2236964g.68: Kazal-type serine protease inhibitors [100894] (1 superfamily)
  66. 2237089g.69: Plant proteinase inhibitors [100896] (1 superfamily)
    disulfide-rich small alpha+beta fold; topological similarity to the Ovomucoid domain III
  67. 2237119g.70: Necrosis inducing protein 1, NIP1 [103579] (1 superfamily)
    disulfide-rich fold; all-beta; duplication: contains two structural repeats
  68. 2237125g.71: Mini-collagen I, C-terminal domain [103588] (1 superfamily)
    disulfide-rich
  69. 2237132g.72: SBT domain [103611] (1 superfamily)
    consist of two different zn-binding subdomains, each subdomain resembles a distorted glucocorticoid receptor-like fold
  70. 2237144g.73: CCHHC domain [103636] (1 superfamily)
    metal(zinc)-bound fold
  71. 2237150g.74: Sec-C motif [103641] (1 superfamily)
    metal(zinc)-bound fold
  72. 2237165g.75: TSP type-3 repeat [103646] (1 superfamily)
    metal(calcium)-bound fold
  73. 2237171g.76: Hormone receptor domain [111417] (1 superfamily)
    disulfide-rich all-beta fold; contains beta sandwich of 5 strands
  74. 2237180g.77: Resistin [111422] (1 superfamily)
    disulfide-rich six-stranded beta-sandwich; jelly-roll
  75. 2237199g.78: YAP1 redox domain [111429] (1 superfamily)
    bipartite cysteine-rich all-alpha domain; a single helix in the N-terminal part (chain A) is linked by disulfides to the C-terminal part (chain B) [3-helical bundle of the RuvA C-terminal domain-like fold (46928)
  76. 2237205g.79: WRKY DNA-binding domain [118289] (1 superfamily)
    zinc-bound 4-stranded meander beta-sheet, distinct from the beta-ribbon motifs
  77. 2237216g.80: AN1-like Zinc finger [118309] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold; partial similarity to the Cysteine-rich domain fold (57888)
  78. 2237237g.81: HSP33 redox switch-like [118351] (1 superfamily)
    alpha+beta zinc-binding domain; alpha(2)-beta(2)-alpha
  79. 2237249g.82: Expressed protein At2g23090/F21P24.15 [118358] (1 superfamily)
    not assigned; partly disordered
  80. 2237255g.83: Tim10-like [144121] (1 superfamily)
    alpha-hairpin crosslinked by two disulfides; assembles into a heterohexameric ring-like structure
  81. 2237272g.84: Cysteine zipper [144128] (1 superfamily)
    string of helices that contain cysteines at almost every turn; folds upon itself and is crosslnked by multiple disulfides
  82. 2237278g.85: HIT/MYND zinc finger-like [144231] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold; structural similarity to members of the Cysteine-rich domain fold (57888)
  83. 2237301g.86: Coronavirus NSP10-like [144245] (1 superfamily)
    binds two zinc ion per subunit; forms a dodecameric shell
  84. 2237361g.87: Viral leader polypeptide zinc finger [144250] (1 superfamily)
    consists of small beta-hairpin with CxH motif and short helix with CxxC motif
  85. 2237367g.88: Intrinsically disordered proteins [144255] (2 superfamilies)
    not a true fold
  86. 2237385g.89: CHY zinc finger-like [161218] (1 superfamily)
    trimetal-bound fold; integration of HIT/MYND-like and rubredoxin-like fingers
  87. 2237394g.90: E6 C-terminal domain-like [161228] (1 superfamily)
    alpha+beta zinc-binding fold with topological similarity to the fold of lambda cro protein
  88. 2237405g.91: E7 C-terminal domain-like [161233] (1 superfamily)
    alpha+beta zinc-binding domain; beta(2)-alpha(2)
  89. 2237416g.92: T-antigen specific domain-like [161239] (1 superfamily)
    all-alpha zinc-binding domain; there are two zinc ion-binding sites with a common CxCxxC motif but different fourth ligands
  90. 2237423g.93: Zinc hairpin stack [161244] (1 superfamily)
    stack of beta-hairpins; in the middle hairpins, there is HCxxCxxC motif, the first and the last residues of which contribute to the zinc-binding site on one side of hairpin, whereas the middle residues contribute to the zinc-binding site on the other side
  91. 2237433g.94: Complement C3 linker domain-like [254109] (1 superfamily)
  92. 2237443g.95: bi-CXXC zinc finger-like [267591] (1 superfamily)
    duplication; dimetal(zinc)-bound fold with little secondary structure
  93. 2237459g.96: Flavivirus non-structural protein NS2B-like [310561] (1 superfamily)
  94. 2237473g.97: Iron-sulfur cluster-binding zinc finger CDGSH type [310565] (1 superfamily)
    Fe-S binding region and beta cap

More info for Class g: Small proteins

Timeline for Class g: Small proteins: