Lineage for Class g: Small proteins

  1. Root: SCOPe 2.08
  2. Class g: Small proteins [56992] (100 folds)

Folds:

  1. g.1: Insulin-like [56993] (1 superfamily)
    nearly all-alpha
    can be classified as disulfide-rich
  2. g.2: Toxic hairpin [57006] (4 superfamilies)
    disulfide crosslinked alpha-helical hairpin
  3. g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. g.4: PMP inhibitors [57282] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  5. g.5: Midkine [57287] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  6. g.6: Amb V allergen [57295] (1 superfamily)
    disulfide-rich; alpha+beta: 3 antiparallel strands followed by a short alpha helix
  7. g.7: Snake toxin-like [57301] (1 superfamily)
    disulfide-rich fold: nearly all-beta
  8. g.8: BPTI-like [57361] (1 superfamily)
    disulfide-rich alpha+beta fold
  9. g.9: Defensin-like [57391] (1 superfamily)
    Disulfide-rich fold, nearly all-beta
  10. g.10: Hairpin loop containing domain-like [57413] (1 superfamily)
    alpha+beta fold with two crossing loops
  11. g.11: Neurotoxin III (ATX III) [57418] (1 superfamily)
    disulfide-rich fold
  12. g.12: LDL receptor-like module [57423] (1 superfamily)
    disulfide-rich calcium-binding fold
  13. g.13: Crambin-like [57428] (1 superfamily)
    disulfide-rich alpha+beta fold
  14. g.14: Kringle-like [57439] (1 superfamily)
    disulfide-rich fold; nearly all-beta
  15. g.16: Trefoil/Plexin domain-like [57491] (3 superfamilies)
    disulfide-rich fold; common core is alpha+beta with two conserved disulfides
  16. g.17: Cystine-knot cytokines [57500] (1 superfamily)
    disulfide-rich fold; common core is all-beta
  17. g.18: Complement control module/SCR domain [57534] (1 superfamily)
    disulfide-rich all-beta fold
  18. g.19: Crisp domain-like [57545] (1 superfamily)
    disulfide-rich all-alpha fold
  19. g.20: Blood coagulation inhibitor (disintegrin) [57551] (1 superfamily)
    small disulfide-rich
  20. g.21: Methylamine dehydrogenase, L chain [57560] (1 superfamily)
    disulfide-rich; nearly all-beta
  21. g.22: Serine protease inhibitors [57566] (1 superfamily)
    disulfide-rich; nearly all-beta
  22. g.23: TB module/8-cys domain [57580] (1 superfamily)
    disulfide-rich; alpha+beta
  23. g.24: TNF receptor-like [57585] (1 superfamily)
    duplication: consists of three similar disulfide-rich domains
  24. g.25: Heparin-binding domain from vascular endothelial growth factor [57592] (1 superfamily)
    duplication: consists of two similar disulfide-rich domains, alpha+beta
  25. g.26: Antifungal protein (AGAFP) [57597] (1 superfamily)
    disulfide-rich; all-beta: open barrel, 5 strands; OB-fold-like
  26. g.27: FnI-like domain [57602] (1 superfamily)
    disulfide-rich, all-beta
  27. g.28: Thyroglobulin type-1 domain [57609] (1 superfamily)
    disulfide-rich, alpha+beta
  28. g.29: Type X cellulose binding domain, CBDX [57614] (1 superfamily)
    disulfide-rich, alpha+beta
  29. g.30: Carboxypeptidase inhibitor [57619] (1 superfamily)
    disulfide-rich, alpha+beta
  30. g.31: Invertebrate chitin-binding proteins [57624] (1 superfamily)
    disulfide-rich
  31. g.32: GLA-domain [57629] (1 superfamily)
    Calcium ion-bound
  32. g.33: Cholecystokinin A receptor, N-domain [57641] (1 superfamily)
    a few helical turns and a disulfide-crosslinked loop
  33. g.34: HIV-1 VPU cytoplasmic domain [57646] (1 superfamily)
    a few helical turns assembled without a hydrophobic core?
  34. g.35: HIPIP (high potential iron protein) [57651] (1 superfamily)
    folds around 4Fe-4S cluster
  35. g.36: Ferredoxin thioredoxin reductase (FTR), catalytic beta chain [57661] (1 superfamily)
    folds around 4Fe-4S cluster
  36. g.37: beta-beta-alpha zinc fingers [57666] (1 superfamily)
    simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC
  37. g.38: Zn2/Cys6 DNA-binding domain [57700] (1 superfamily)
    all-alpha dimetal(zinc)-bound fold
  38. g.39: Glucocorticoid receptor-like (DNA-binding domain) [57715] (1 superfamily)
    alpha+beta metal(zinc)-bound fold
  39. g.40: Retrovirus zinc finger-like domains [57755] (1 superfamily)
    metal(zinc)-bound fold
  40. g.41: Rubredoxin-like [57769] (17 superfamilies)
    metal(zinc or iron)-bound fold; sequence contains two CX(n)C motifs, in most cases n = 2
  41. g.42: Ribosomal protein L36 [57839] (1 superfamily)
    zinc-bound beta-ribbon motif
  42. g.43: B-box zinc-binding domain [57844] (1 superfamily)
    zinc-bound alpha+beta motif
  43. g.44: RING/U-box [57849] (1 superfamily)
    dimetal(zinc)-bound alpha+beta motif; structurally diverse
  44. g.45: ArfGap/RecO-like zinc finger [57862] (1 superfamily)
    zinc-bound alpha+beta motif
  45. g.46: Metallothionein [57867] (1 superfamily)
    metal(iron)-bound fold
    duplication: consists of clear structural/sequence repeats
  46. g.47: Zinc domain conserved in yeast copper-regulated transcription factors [57878] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  47. g.48: Ada DNA repair protein, N-terminal domain (N-Ada 10) [57883] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  48. g.49: Cysteine-rich domain [57888] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold
  49. g.50: FYVE/PHD zinc finger [57902] (2 superfamilies)
    dimetal(zinc)-bound alpha+beta fold
  50. g.51: Zn-binding domains of ADDBP [57916] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  51. g.52: Inhibitor of apoptosis (IAP) repeat [57923] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  52. g.53: TAZ domain [57932] (1 superfamily)
    all-alpha fold; Zn-binding sites are in the loops connecting helices
  53. g.54: DnaJ/Hsp40 cysteine-rich domain [57937] (1 superfamily)
    metal(zinc)-bound extended beta-hairpin fold
  54. g.55: Cellulose docking domain, dockering [64570] (1 superfamily)
    disulfide-rich, alpha+beta
  55. g.58: Pheromone ER-23 [69963] (1 superfamily)
    disulfide-rich, all-alpha
  56. g.59: Zinc-binding domain of translation initiation factor 2 beta [75688] (1 superfamily)
    zinc-bound beta-ribbon motif
  57. g.60: TSP-1 type 1 repeat [82894] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  58. g.61: Apical membrane antigen 1 [82909] (1 superfamily)
    disulfide-rich, alpha+beta
  59. g.62: Cysteine-rich DNA binding domain, (DM domain) [82926] (1 superfamily)
    alpha-helical fold with two Zn-binding sites
  60. g.63: Mollusk pheromone [90182] (1 superfamily)
    disulfide-rich; all-alpha
  61. g.64: Somatomedin B domain [90187] (1 superfamily)
    disulfide-rich
  62. g.65: Notch domain [90192] (1 superfamily)
    disulfide-rich; all-alpha; calcium-binding
  63. g.66: CCCH zinc finger [90228] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  64. g.67: Zinc finger domain of DNA polymerase-alpha [90233] (1 superfamily)
    Zn-binding, all-alpha fold
  65. g.68: Kazal-type serine protease inhibitors [100894] (1 superfamily)
  66. g.69: Plant proteinase inhibitors [100896] (1 superfamily)
    disulfide-rich small alpha+beta fold; topological similarity to the Ovomucoid domain III
  67. g.70: Necrosis inducing protein 1, NIP1 [103579] (1 superfamily)
    disulfide-rich fold; all-beta; duplication: contains two structural repeats
  68. g.71: Mini-collagen I, C-terminal domain [103588] (1 superfamily)
    disulfide-rich
  69. g.72: SBT domain [103611] (1 superfamily)
    consist of two different zn-binding subdomains, each subdomain resembles a distorted glucocorticoid receptor-like fold
  70. g.73: CCHHC domain [103636] (1 superfamily)
    metal(zinc)-bound fold
  71. g.74: Sec-C motif [103641] (1 superfamily)
    metal(zinc)-bound fold
  72. g.75: TSP type-3 repeat [103646] (1 superfamily)
    metal(calcium)-bound fold
  73. g.76: Hormone receptor domain [111417] (1 superfamily)
    disulfide-rich all-beta fold; contains beta sandwich of 5 strands
  74. g.77: Resistin [111422] (1 superfamily)
    disulfide-rich six-stranded beta-sandwich; jelly-roll
  75. g.78: YAP1 redox domain [111429] (1 superfamily)
    bipartite cysteine-rich all-alpha domain; a single helix in the N-terminal part (chain A) is linked by disulfides to the C-terminal part (chain B) [3-helical bundle of the RuvA C-terminal domain-like fold (46928)
  76. g.79: WRKY DNA-binding domain [118289] (1 superfamily)
    zinc-bound 4-stranded meander beta-sheet, distinct from the beta-ribbon motifs
  77. g.80: AN1-like Zinc finger [118309] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold; partial similarity to the Cysteine-rich domain fold (57888)
  78. g.81: HSP33 redox switch-like [118351] (1 superfamily)
    alpha+beta zinc-binding domain; alpha(2)-beta(2)-alpha
  79. g.82: Expressed protein At2g23090/F21P24.15 [118358] (1 superfamily)
    not assigned; partly disordered
  80. g.83: Tim10-like [144121] (1 superfamily)
    alpha-hairpin crosslinked by two disulfides; assembles into a heterohexameric ring-like structure
  81. g.84: Cysteine zipper [144128] (1 superfamily)
    string of helices that contain cysteines at almost every turn; folds upon itself and is crosslnked by multiple disulfides
  82. g.85: HIT/MYND zinc finger-like [144231] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold; structural similarity to members of the Cysteine-rich domain fold (57888)
  83. g.86: Coronavirus NSP10-like [144245] (1 superfamily)
    binds two zinc ion per subunit; forms a dodecameric shell
  84. g.87: Viral leader polypeptide zinc finger [144250] (1 superfamily)
    consists of small beta-hairpin with CxH motif and short helix with CxxC motif
  85. g.88: Intrinsically disordered proteins [144255] (2 superfamilies)
    not a true fold
    annotated by the SCOP(e) curators as 'not a true fold'
  86. g.89: CHY zinc finger-like [161218] (1 superfamily)
    trimetal-bound fold; integration of HIT/MYND-like and rubredoxin-like fingers
  87. g.90: E6 C-terminal domain-like [161228] (1 superfamily)
    alpha+beta zinc-binding fold with topological similarity to the fold of lambda cro protein
  88. g.91: E7 C-terminal domain-like [161233] (1 superfamily)
    alpha+beta zinc-binding domain; beta(2)-alpha(2)
  89. g.92: T-antigen specific domain-like [161239] (1 superfamily)
    all-alpha zinc-binding domain; there are two zinc ion-binding sites with a common CxCxxC motif but different fourth ligands
  90. g.93: Zinc hairpin stack [161244] (1 superfamily)
    stack of beta-hairpins; in the middle hairpins, there is HCxxCxxC motif, the first and the last residues of which contribute to the zinc-binding site on one side of hairpin, whereas the middle residues contribute to the zinc-binding site on the other side
  91. g.94: Complement C3 linker domain-like [254109] (1 superfamily)
  92. g.95: bi-CXXC zinc finger-like [267591] (1 superfamily)
    duplication; dimetal(zinc)-bound fold with little secondary structure
  93. g.96: Flavivirus non-structural protein NS2B-like [310561] (1 superfamily)
  94. g.97: Iron-sulfur cluster-binding zinc finger CDGSH type [310565] (1 superfamily)
    Fe-S binding region and beta cap
  95. g.98: RNA polymerase I subunit A14-like [345896] (1 superfamily)
    alpha hairpin with 2 beta strands involved in heterodimeric interactions
  96. g.99: Pre-mRNA splicing factor Cwf14-like [345897] (1 superfamily)
    9 conserved Cys bind 3 zinc. Also includes N-terminal helical bundle
  97. g.100: Pre-mRNA splicing factor Cwf5-like [345898] (1 superfamily)
    alpha + beta fold, with 4 CxxC motifs that bind 2 zinc ions
  98. g.101: Triquetra knot [345899] (1 superfamily)
    Triangular knot binding 3 zinc ions
  99. g.102: Jumonji C-terminal domain-like [418708] (1 superfamily)
    alpha + beta fold, with C5HC2 zinc finger binding 2 zinc ions
  100. g.103: Protein-only RNAse P central domain-like [418734] (1 superfamily)
    core: 4-stranded antiparallel beta sheet that coordinates zinc, order 1432

More info for Class g: Small proteins

Timeline for Class g: Small proteins: