Structural Classification of Proteins and ASTRAL release 1.75B (January 2013)
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Lineage for Fold g.3: Knottins (small inhibitors, toxins, lectins)

  1. Root: SCOP 1.75B
  2. Class g: Small proteins [56992] (90 folds)
  3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

Superfamilies:

  1. g.3.1: Plant lectins/antimicrobial peptides [57016] (2 families) (S)
  2. g.3.2: Plant inhibitors of proteinases and amylases [57027] (1 family) (S)
  3. g.3.3: Cyclotides [57038] (4 families) (S)
    macrocyclic plant knottins closed with the formation of an Asn-Gly peptide
  4. g.3.4: Gurmarin-like [57048] (2 families) (S)
  5. g.3.5: Agouti-related protein [57055] (1 family) (S)
  6. g.3.6: omega toxin-like [57059] (5 families) (S)
  7. g.3.7: Scorpion toxin-like [57095] (5 families) (S)
  8. g.3.8: Cellulose-binding domain [57180] (1 family) (S)
  9. g.3.9: Growth factor receptor domain [57184] (1 family) (S)
  10. g.3.10: Colipase-like [57190] (1 family) (S)
  11. g.3.11: EGF/Laminin [57196] (7 families) (S)
  12. g.3.12: Bromelain inhibitor VI (cysteine protease inhibitor) [57243] (1 family) (S)
  13. g.3.13: Bowman-Birk inhibitor, BBI [57247] (1 family) (S)
  14. g.3.14: Elafin-like [57256] (1 family) (S)
  15. g.3.15: Leech antihemostatic proteins [57262] (3 families) (S)
  16. g.3.16: Granulin repeat [57277] (1 family) (S)
  17. g.3.17: Satiety factor CART (cocaine and amphetamine regulated transcript) [64546] (1 family) (S)
  18. g.3.18: DPY module [90148] (1 family) (S)
  19. g.3.19: Bubble protein [103565] (1 family) (S)

More info for Fold g.3: Knottins (small inhibitors, toxins, lectins)

Timeline for Fold g.3: Knottins (small inhibitors, toxins, lectins):

Fold g.3: Knottins (small inhibitors, toxins, lectins) appears in SCOP 1.75A

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