SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold g.3: Knottins (small inhibitors, toxins, lectins)

  1. Root: SCOPe 2.06
  2. 2229111Class g: Small proteins [56992] (94 folds)
  3. 2229389Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

Superfamilies:

  1. 2229390g.3.1: Plant lectins/antimicrobial peptides [57016] (3 families) (S)
  2. 2229588g.3.2: Plant inhibitors of proteinases and amylases [57027] (1 family) (S)
  3. 2229647g.3.3: Cyclotides [57038] (4 families) (S)
    macrocyclic plant knottins closed with the formation of an Asn-Gly peptide
  4. 2229696g.3.4: Gurmarin-like [57048] (2 families) (S)
  5. 2229709g.3.5: Agouti-related protein [57055] (1 family) (S)
    automatically mapped to Pfam PF05039
  6. 2229715g.3.6: omega toxin-like [57059] (5 families) (S)
  7. 2229881g.3.7: Scorpion toxin-like [57095] (5 families) (S)
  8. 2230242g.3.8: Cellulose-binding domain [57180] (1 family) (S)
  9. 2230252g.3.9: Growth factor receptor domain [57184] (2 families) (S)
  10. 2230346g.3.10: Colipase-like [57190] (2 families) (S)
  11. 2230373g.3.11: EGF/Laminin [57196] (8 families) (S)
  12. 2231049g.3.12: Bromelain inhibitor VI (cysteine protease inhibitor) [57243] (1 family) (S)
  13. 2231057g.3.13: Bowman-Birk inhibitor, BBI [57247] (2 families) (S)
  14. 2231108g.3.14: Elafin-like [57256] (2 families) (S)
    automatically mapped to Pfam PF00095
  15. 2231121g.3.15: Leech antihemostatic proteins [57262] (3 families) (S)
  16. 2231171g.3.16: Granulin repeat [57277] (1 family) (S)
  17. 2231183g.3.17: Satiety factor CART (cocaine and amphetamine regulated transcript) [64546] (1 family) (S)
    automatically mapped to Pfam PF06373
  18. 2231188g.3.18: DPY module [90148] (1 family) (S)
  19. 2231193g.3.19: Bubble protein [103565] (1 family) (S)
    automatically mapped to Pfam PF09227

More info for Fold g.3: Knottins (small inhibitors, toxins, lectins)

Timeline for Fold g.3: Knottins (small inhibitors, toxins, lectins):