Lineage for Fold g.3: Knottins (small inhibitors, toxins, lectins)

  1. Root: SCOPe 2.06
  2. 2229111Class g: Small proteins [56992] (94 folds)
  3. 2229389Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

Superfamilies:

  1. 2229390g.3.1: Plant lectins/antimicrobial peptides [57016] (3 families) (S)
  2. 2229588g.3.2: Plant inhibitors of proteinases and amylases [57027] (1 family) (S)
  3. 2229647g.3.3: Cyclotides [57038] (4 families) (S)
    macrocyclic plant knottins closed with the formation of an Asn-Gly peptide
  4. 2229696g.3.4: Gurmarin-like [57048] (2 families) (S)
  5. 2229709g.3.5: Agouti-related protein [57055] (1 family) (S)
    automatically mapped to Pfam PF05039
  6. 2229715g.3.6: omega toxin-like [57059] (5 families) (S)
  7. 2229881g.3.7: Scorpion toxin-like [57095] (6 families) (S)
  8. 2230242g.3.8: Cellulose-binding domain [57180] (1 family) (S)
  9. 2230252g.3.9: Growth factor receptor domain [57184] (2 families) (S)
  10. 2230346g.3.10: Colipase-like [57190] (2 families) (S)
  11. 2230373g.3.11: EGF/Laminin [57196] (8 families) (S)
  12. 2231049g.3.12: Bromelain inhibitor VI (cysteine protease inhibitor) [57243] (1 family) (S)
  13. 2231057g.3.13: Bowman-Birk inhibitor, BBI [57247] (2 families) (S)
  14. 2231108g.3.14: Elafin-like [57256] (2 families) (S)
    automatically mapped to Pfam PF00095
  15. 2231121g.3.15: Leech antihemostatic proteins [57262] (3 families) (S)
  16. 2231171g.3.16: Granulin repeat [57277] (1 family) (S)
  17. 2231183g.3.17: Satiety factor CART (cocaine and amphetamine regulated transcript) [64546] (1 family) (S)
    automatically mapped to Pfam PF06373
  18. 2231188g.3.18: DPY module [90148] (1 family) (S)
  19. 2231193g.3.19: Bubble protein [103565] (1 family) (S)
    automatically mapped to Pfam PF09227

More info for Fold g.3: Knottins (small inhibitors, toxins, lectins)

Timeline for Fold g.3: Knottins (small inhibitors, toxins, lectins):