SCOPe 2.07: Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase

Lineage for Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.96: T-fold [55619] (2 superfamilies)
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families)
   bind purine or pterin in topologically similar sites between subunits

5. Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase [55625] (2 proteins)

Proteins:

1. 6-pyruvoyl tetrahydropterin synthase [55626] (4 species)
   beta-sheets of three subunits form a barrel, closed: n=12, S=12

   1. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [118057] (1 PDB entry)
      Uniprot Q6LEZ4

   2. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [143628] (1 PDB entry)
      Uniprot O02058 1-139

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [55627] (3 PDB entries)

   4. Species Plasmodium vivax [TaxId:5855] [143629] (1 PDB entry)
      73% similarity to the Plasmodium falciparum enzyme

2. automated matches [191141] (1 species)
   not a true protein

   • Species Plasmodium vivax [TaxId:5855] [189269] (3 PDB entries)

More info for Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase

Timeline for Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase:

• Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase first appeared (with stable ids) in SCOP 1.55
  
• Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase appears in SCOPe 2.06
  
• Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase appears in the current release, SCOPe 2.08