SCOP 1.71: Protein: Heterochromatin protein 1, HP1

Lineage for Protein: Heterochromatin protein 1, HP1

Root: SCOP 1.71
Class b: All beta proteins [48724] (149 folds)
Fold b.34: SH3-like barrel [50036] (15 superfamilies)
barrel, partly opened; n*=4, S*=8; meander
the last strand is interrupted by a turn of 3-10 helix
Superfamily b.34.13: Chromo domain-like [54160] (3 families)
SH3-like barrel is capped by a C-terminal helix

Family b.34.13.2: Chromo domain [54165] (3 proteins)
lacks the SH3-like barrel first strand that can be complemented by bound peptide ligand; in shadow chromo domain the corresponding site is altered by insertion; similarity to the IL8-like fold

Protein Heterochromatin protein 1, HP1 [54166] (3 species)
duplication: consists of two homologous domains, N-terminal chromo domain and C-terminal chromo shadow domain

Species:

Fission yeast (Schizosaccharomyces pombe), SWI6 [TaxId:4896] [54169] (1 PDB entry)
- Domains for 1e0b:
  1. Domain d1e0ba_: 1e0b A: [37476]
  2. Domain d1e0bb_: 1e0b B: [37477]
    C-terminal shadow chromo domain
    complexed with 1pg
Fruit fly (Drosophila melanogaster) [TaxId:7227] [75343] (3 PDB entries)
1. Domain for 1kna:
  - Domain d1knaa_: 1kna A: [72771]
    Chromo domain complexed with histone h3 tail containing dimethyllysine 9
    complexed with mly; mutant
2. Domain for 1kne:
  - Domain d1knea_: 1kne A: [72774]
    Chromo domain complexed with histone h3 tail containing trimethyllysine 9
    complexed with m3l; mutant
3. Domain for 1q3l:
  - Domain d1q3la_: 1q3l A: [111652]
    complexed with histone H3 tail containing monomethyllysine 9 (SQ P16106 5-10), chain P
    complexed with mlz
Mouse (Mus musculus), HP1 beta (MOD1, M31) [TaxId:10090] [54167] (4 PDB entries)
1. Domain for 1ap0:
  - Domain d1ap0__: 1ap0 - [37475]
    N-terminal chromo domain
    mutant
2. Domains for 1dz1:
  1. Domain d1dz1a_: 1dz1 A: [37473]
  2. Domain d1dz1b_: 1dz1 B: [37474]
    C-terminal shadow chromo domain
3. Domain for 1guw:
  - Domain d1guwa_: 1guw A: [70584]
    Chromo domain complexed with the lysine 9-methyl histone H3 N-terminal peptide
    complexed with mly
4. Domains for 1s4z:
  1. Domain d1s4za_: 1s4z A: [98515]
  2. Domain d1s4zb_: 1s4z B: [98516]
    Chromo shadow domain complexed with pxvxl motif peptide of caf-1, chain C

More info for Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain

Timeline for Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain:

Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain first appeared (with stable ids) in SCOP 1.55, called Protein Modifier protein 1 (M31, HP1 beta) from d.9.2.2: Chromo domain
Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain appears in SCOP 1.69
Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain appears in SCOP 1.73
Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain appears in the current release, SCOPe 2.08