Lineage for Protein: Heterochromatin protein 1, HP1

  1. Root: SCOP 1.73
  2. 651986Class b: All beta proteins [48724] (165 folds)
  3. 665027Fold b.34: SH3-like barrel [50036] (18 superfamilies)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
  4. 665974Superfamily b.34.13: Chromo domain-like [54160] (3 families) (S)
    SH3-like barrel is capped by a C-terminal helix
  5. 665998Family b.34.13.2: Chromo domain [54165] (7 proteins)
    lacks the SH3-like barrel first strand that can be complemented by bound peptide ligand; in shadow chromo domain the corresponding site is altered by insertion; similarity to the IL8-like fold
  6. 666040Protein Heterochromatin protein 1, HP1 [54166] (3 species)
    duplication: consists of two homologous domains, N-terminal chromo domain and C-terminal chromo shadow domain

Species:

  1. 666041Fission yeast (Schizosaccharomyces pombe), SWI6 [TaxId:4896] [54169] (1 PDB entry)
  2. 666044Fruit fly (Drosophila melanogaster) [TaxId:7227] [75343] (3 PDB entries)
    1. Domain for 1kna:
      • 666046Domain d1knaa_: 1kna A: [72771]
        Chromo domain complexed with histone h3 tail containing dimethyllysine 9
        complexed with mly; mutant
    2. Domain for 1kne:
      • 666047Domain d1knea_: 1kne A: [72774]
        Chromo domain complexed with histone h3 tail containing trimethyllysine 9
        complexed with m3l; mutant
    3. Domain for 1q3l:
      • 666045Domain d1q3la_: 1q3l A: [111652]
        complexed with histone H3 tail containing monomethyllysine 9 (SQ P16106 5-10), chain P
        complexed with mlz
  3. 666048Mouse (Mus musculus), HP1 beta (MOD1, M31) [TaxId:10090] [54167] (5 PDB entries)
    1. Domain for 1ap0:
    2. Domains for 1dz1:
      1. 666053Domain d1dz1a_: 1dz1 A: [37473]
      2. 666054Domain d1dz1b_: 1dz1 B: [37474]
        C-terminal shadow chromo domain
    3. Domain for 1guw:
      • 666055Domain d1guwa_: 1guw A: [70584]
        Chromo domain complexed with the lysine 9-methyl histone H3 N-terminal peptide
        complexed with mly
    4. Domains for 1s4z:
      1. 666056Domain d1s4za_: 1s4z A: [98515]
      2. 666057Domain d1s4zb_: 1s4z B: [98516]
        Chromo shadow domain complexed with pxvxl motif peptide of caf-1, chain C
    5. Domains for 2fmm:
      1. 666049Domain d2fmma1: 2fmm A:108-175 [133782]
        automatically matched to d1s4za_
        complexed with so4
      2. 666050Domain d2fmmb1: 2fmm B:109-175 [133783]
        automatically matched to d1s4za_
        complexed with so4
      3. 666051Domain d2fmmc1: 2fmm C:109-175 [133784]
        automatically matched to d1s4za_
        complexed with so4
      4. 666052Domain d2fmmd1: 2fmm D:110-175 [133785]
        automatically matched to d1s4za_
        complexed with so4

More info for Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain

Timeline for Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain: