Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOPe 2.03
  2. 1336837Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1346342Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1346343Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1346668Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

  1. 1346669(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 1346675(s)-1-phenylethanol dehydrogenase [141902] (1 species)
  3. 13466801,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  4. 13466831,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  5. 134669511-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
    1. 1346696Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
      Uniprot Q6QLL4 23-296
    2. 1346711Species Human (Homo sapiens) [TaxId:9606] [117424] (24 PDB entries)
      Uniprot P28845
    3. 1346799Species Mouse (Mus musculus) [TaxId:10090] [141879] (5 PDB entries)
      Uniprot P50172 24-298
  6. 134681615-hydroxyprostaglandin dehydrogenase, PGDH [141888] (1 species)
  7. 134681917-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  8. 13468232,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  9. 13468373-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  10. 13468473-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  11. 13468533beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  12. 13468597-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  13. 1346867ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  14. 1346879Aldehyde reductase II [117413] (1 species)
  15. 1346887Bacterial sepiapterin reductase [141892] (1 species)
  16. 1346893beta-keto acyl carrier protein reductase [51788] (8 species)
    1. 1346894Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 1346909Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141877] (1 PDB entry)
      Uniprot Q86RB1 54-304
    3. 1346911Species Mycobacterium tuberculosis [TaxId:1773] [141875] (2 PDB entries)
      Uniprot P0A5Y4 9-245! Uniprot P0A5Y4 9-247
    4. 1346914Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (2 PDB entries)
    5. 1346922Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
      Uniprot P16544 #SP
    6. 1346939Species Thermotoga maritima [TaxId:2336] [102150] (1 PDB entry)
      TM1169
    7. 1346944Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
      Uniprot Q5SK98
    8. 1346953Species Thermus thermophilus, TTHB020 [TaxId:274] [141876] (1 PDB entry)
      Uniprot Q53WH2 2-242
  17. 1346956Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  18. 1346963Carbonyl reductase [51765] (2 species)
    1. 1346964Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 1346967Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  19. 1346972Carbonyl reductase sniffer [110413] (2 species)
    1. 1346973Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [110414] (1 PDB entry)
      Uniprot Q9W3H4 # cg10964-pa
    2. 1346975Species Nematode (Caenorhabditis elegans) [TaxId:6239] [186880] (1 PDB entry)
  20. 1346981Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (2 species)
    1. 1346982Species Human (Homo sapiens) [TaxId:9606] [141878] (5 PDB entries)
      Uniprot P16152 2-276
    2. 1346988Species Pig (Sus scrofa) [TaxId:9823] [63936] (1 PDB entry)
  21. 1346990CDP-glucose-4,6-dehydratase [102136] (3 species)
    1. 1346991Species Salmonella enterica [TaxId:220341] [190019] (1 PDB entry)
    2. 1346993Species Salmonella typhimurium [TaxId:90371] [141873] (1 PDB entry)
      Uniprot P26397 2-356
    3. 1346995Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)
  22. 1347000CDP-tyvelose-2-epimerase [102138] (1 species)
  23. 1347006Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  24. 1347009D(-)-3-hydroxybutyrate dehydrogenase [141886] (1 species)
  25. 1347012Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
    Oxidoreductase UCPA
  26. 1347015Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
    1. 1347016Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 1347018Species Leishmania major [TaxId:5664] [63926] (10 PDB entries)
      Uniprot Q01782
    3. 1347065Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 1347070Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 1347073Species Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 1347079Species Trypanosoma brucei [TaxId:5702] [226783] (7 PDB entries)
    7. 1347108Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  27. 1347117Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 1347118Species Fly (Drosophila lebanonensis) [TaxId:7225] [51783] (8 PDB entries)
    2. 1347138Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  28. 1347141DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  29. 1347146dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)
  30. 1347152dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 1347153Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 1347156Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 1347161Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 1347174Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  31. 1347177Enoyl-ACP reductase [51791] (11 species)
    1. 1347178Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188487] (1 PDB entry)
    2. 1347183Species Bacillus cereus [TaxId:226900] [192761] (1 PDB entry)
    3. 1347187Species Bacillus subtilis [TaxId:1423] [189591] (2 PDB entries)
    4. 1347193Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    5. 1347230Species Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    6. 1347239Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
      Uniprot Q9BJJ9 96-424 # fragment
    7. 1347287Species Mycobacterium leprae [TaxId:1769] [187924] (1 PDB entry)
    8. 1347290Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (44 PDB entries)
    9. 1347395Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    10. 1347401Species Staphylococcus aureus [TaxId:1280] [189086] (3 PDB entries)
    11. 1347409Species Thermus thermophilus [TaxId:274] [117409] (1 PDB entry)
      Uniprot Q5SLI9
  32. 1347414Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
  33. 1347420GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  34. 1347430GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 1347431Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 1347433Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
    3. 1347438Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 1347443Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  35. 1347450GDP-mannose-3', 5'-epimerase [141890] (1 species)
  36. 1347456Gluconate 5-dehydrogenase [110411] (1 species)
  37. 1347460Glucose dehydrogenase [51784] (1 species)
  38. 1347478Glucose dehydrogenase (5l265) [102155] (1 species)
  39. 1347481Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  40. 1347513Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  41. 1347545Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  42. 1347555Hypothetical protein F25D1.5 [110415] (1 species)
  43. 1347559Hypothetical protein PA4017 [141911] (1 species)
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
  44. 1347563Hypothetical protein R05D8.7 [117415] (1 species)
  45. 1347569Hypothetical protein TTHA0369 [141896] (1 species)
    TT0321
  46. 1347572Levodione reductase [89523] (1 species)
  47. 1347582Mannitol dehydrogenase [63927] (1 species)
  48. 1347596meso-2,3-butanediol dehydrogenase [51786] (1 species)
  49. 1347606Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  50. 1347614Peroxisomal multifunctional enzyme type 2 [141900] (1 species)
    17-beta-hydroxysteroid dehydrogenase 4
  51. 1347622Peroxisomal trans 2-enoyl CoA reductase [141884] (1 species)
  52. 1347628Phenylcoumaran benzylic ether reductase [102140] (1 species)
  53. 1347632Pinoresinol-lariciresinol reductase [102142] (1 species)
  54. 1347638Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  55. 1347652Putative carbonyl reductase sniffer [141913] (1 species)
  56. 1347655Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  57. 1347661Putative oxidoreductase Rv2002 [82292] (1 species)
  58. 1347673R-specific alcohol dehydrogenase [89521] (1 species)
  59. 1347677Retinal dehydrogenase/reductase 3 [141907] (1 species)
  60. 1347680Rhizome secoisolariciresinol dehydrogenase [141898] (1 species)
  61. 1347683Sepiapterin reductase [51767] (2 species)
    1. 1347684Species Human (Homo sapiens) [TaxId:9606] [141874] (1 PDB entry)
      Uniprot P35270 5-261
    2. 1347691Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
  62. 1347695Sorbitol dehydrogenase [102148] (1 species)
  63. 1347699Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  64. 1347705TAT-interacting protein TIP30 [141904] (2 species)
    1. 1347706Species Human (Homo sapiens) [TaxId:9606] [141905] (1 PDB entry)
      Uniprot Q9BUP3 5-236
    2. 1347708Species Mouse (Mus musculus) [TaxId:10090] [141906] (1 PDB entry)
      Uniprot Q9Z2G9 7-236
  65. 1347710Tropinone reductase [51795] (3 species)
    1. 1347711Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 1347714Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 1347722Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (1 PDB entry)
      Uniprot Q9ASX2
  66. 1347724Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 1347725Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
      Uniprot Q99714
    2. 1347731Species Norway rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 1347744Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  67. 1347747UDP-glucuronate decarboxylase 1 [141880] (1 species)
  68. 1347750UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  69. 1347754Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)
    1. 1347755Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
      Uniprot P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
    2. 1347757Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    3. 1347776Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    4. 1347790Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [89519] (1 PDB entry)
  70. 1347795Xylitol dehydrogenase [141882] (1 species)
  71. 1347798automated matches [190085] (38 species)
    not a true protein
    1. 1347799Species Alcaligenes faecalis [TaxId:511] [188427] (5 PDB entries)
    2. 1347815Species Alfalfa (Medicago sativa) [TaxId:3879] [187740] (1 PDB entry)
    3. 1347818Species Aquifex aeolicus [TaxId:224324] [188271] (2 PDB entries)
    4. 1347827Species Bacillus anthracis [TaxId:198094] [188031] (1 PDB entry)
    5. 1347836Species Bacillus megaterium [TaxId:1404] [195340] (5 PDB entries)
    6. 1347849Species Burkholderia pseudomallei [TaxId:320372] [188614] (1 PDB entry)
    7. 1347854Species Burkholderia pseudomallei [TaxId:884204] [238338] (1 PDB entry)
    8. 1347856Species Comamonas testosteroni [TaxId:285] [189779] (3 PDB entries)
    9. 1347863Species Eimeria tenella [TaxId:413949] [187997] (1 PDB entry)
    10. 1347866Species Emericella nidulans [TaxId:162425] [187249] (3 PDB entries)
    11. 1347891Species Escherichia coli K-12 [TaxId:83333] [189924] (3 PDB entries)
    12. 1347898Species Francisella tularensis [TaxId:177416] [189289] (1 PDB entry)
    13. 1347903Species Francisella tularensis [TaxId:263] [188795] (1 PDB entry)
    14. 1347908Species Human (Homo sapiens) [TaxId:9606] [186828] (8 PDB entries)
    15. 1347943Species Lactobacillus brevis [TaxId:1580] [186912] (6 PDB entries)
    16. 1347957Species Leishmania donovani [TaxId:5661] [189607] (1 PDB entry)
    17. 1347960Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [186807] (1 PDB entry)
    18. 1347962Species Mycobacterium tuberculosis [TaxId:83332] [229356] (1 PDB entry)
    19. 1347969Species Neisseria meningitidis [TaxId:272831] [228105] (3 PDB entries)
    20. 1347976Species Pandoraea pnomenusa [TaxId:93220] [189780] (3 PDB entries)
    21. 1347983Species Plasmodium berghei [TaxId:5821] [189246] (1 PDB entry)
    22. 1347988Species Plasmodium falciparum [TaxId:36329] [228763] (2 PDB entries)
    23. 1347993Species Plesiomonas shigelloides [TaxId:703] [189972] (9 PDB entries)
    24. 1348028Species Pseudomonas fragi [TaxId:296] [188080] (6 PDB entries)
    25. 1348047Species Pseudomonas putida [TaxId:303] [188252] (3 PDB entries)
    26. 1348064Species Rhizobium radiobacter [TaxId:358] [197100] (3 PDB entries)
    27. 1348071Species Sinorhizobium meliloti [TaxId:266834] [195628] (1 PDB entry)
    28. 1348076Species Staphylococcus aureus [TaxId:282458] [193773] (1 PDB entry)
    29. 1348078Species Streptomyces coelicolor [TaxId:1902] [189970] (5 PDB entries)
    30. 1348089Species Streptomyces griseoruber [TaxId:1943] [196180] (1 PDB entry)
    31. 1348092Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [187183] (5 PDB entries)
    32. 1348098Species Thermus thermophilus [TaxId:274] [187600] (1 PDB entry)
    33. 1348102Species Thermus thermophilus [TaxId:300852] [187188] (4 PDB entries)
    34. 1348123Species Toxoplasma gondii [TaxId:383379] [187942] (3 PDB entries)
    35. 1348134Species Trypanosoma brucei [TaxId:5702] [187520] (4 PDB entries)
    36. 1348151Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [187036] (1 PDB entry)
    37. 1348156Species Vibrio cholerae [TaxId:243277] [189479] (7 PDB entries)
    38. 1348169Species Vibrio cholerae [TaxId:593588] [189768] (3 PDB entries)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: