Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOPe 2.02
  2. 1143363Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1150729Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1150730Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1151047Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

  1. 1151048(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 1151054(s)-1-phenylethanol dehydrogenase [141902] (1 species)
  3. 11510591,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  4. 11510621,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  5. 115107411-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
    1. 1151075Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
      Uniprot Q6QLL4 23-296
    2. 1151090Species Human (Homo sapiens) [TaxId:9606] [117424] (20 PDB entries)
      Uniprot P28845
    3. 1151163Species Mouse (Mus musculus) [TaxId:10090] [141879] (3 PDB entries)
      Uniprot P50172 24-298
  6. 115117615-hydroxyprostaglandin dehydrogenase, PGDH [141888] (1 species)
  7. 115117917-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  8. 11511832,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  9. 11511973-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  10. 11512073-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  11. 11512133beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  12. 11512197-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  13. 1151227ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  14. 1151239Aldehyde reductase II [117413] (1 species)
  15. 1151247Bacterial sepiapterin reductase [141892] (1 species)
  16. 1151253beta-keto acyl carrier protein reductase [51788] (8 species)
    1. 1151254Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 1151269Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141877] (1 PDB entry)
      Uniprot Q86RB1 54-304
    3. 1151271Species Mycobacterium tuberculosis [TaxId:1773] [141875] (2 PDB entries)
      Uniprot P0A5Y4 9-245! Uniprot P0A5Y4 9-247
    4. 1151274Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (2 PDB entries)
    5. 1151282Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
      Uniprot P16544 #SP
    6. 1151298Species Thermotoga maritima [TaxId:2336] [102150] (1 PDB entry)
      TM1169
    7. 1151303Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
      Uniprot Q5SK98
    8. 1151312Species Thermus thermophilus, TTHB020 [TaxId:274] [141876] (1 PDB entry)
      Uniprot Q53WH2 2-242
  17. 1151315Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  18. 1151322Carbonyl reductase [51765] (2 species)
    1. 1151323Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 1151326Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  19. 1151331Carbonyl reductase sniffer [110413] (2 species)
    1. 1151332Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [110414] (1 PDB entry)
      Uniprot Q9W3H4 # cg10964-pa
    2. 1151334Species Nematode (Caenorhabditis elegans) [TaxId:6239] [186880] (1 PDB entry)
  20. 1151340Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (2 species)
    1. 1151341Species Human (Homo sapiens) [TaxId:9606] [141878] (5 PDB entries)
      Uniprot P16152 2-276
    2. 1151347Species Pig (Sus scrofa) [TaxId:9823] [63936] (1 PDB entry)
  21. 1151349CDP-glucose-4,6-dehydratase [102136] (3 species)
    1. 1151350Species Salmonella enterica [TaxId:220341] [190019] (1 PDB entry)
    2. 1151352Species Salmonella typhimurium [TaxId:90371] [141873] (1 PDB entry)
      Uniprot P26397 2-356
    3. 1151354Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)
  22. 1151359CDP-tyvelose-2-epimerase [102138] (1 species)
  23. 1151365Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  24. 1151368D(-)-3-hydroxybutyrate dehydrogenase [141886] (1 species)
  25. 1151371Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
    Oxidoreductase UCPA
  26. 1151374Dihydropteridin reductase (pteridine reductase) [51769] (6 species)
    1. 1151375Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 1151377Species Leishmania major [TaxId:5664] [63926] (10 PDB entries)
      Uniprot Q01782
    3. 1151424Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 1151429Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 1151432Species Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 1151438Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  27. 1151447Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 1151448Species Fly (Drosophila lebanonensis) [TaxId:7225] [51783] (7 PDB entries)
    2. 1151461Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  28. 1151464DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  29. 1151469dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)
  30. 1151475dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 1151476Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 1151479Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 1151484Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 1151497Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  31. 1151500Enoyl-ACP reductase [51791] (11 species)
    1. 1151501Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188487] (1 PDB entry)
    2. 1151503Species Bacillus cereus [TaxId:226900] [192761] (1 PDB entry)
    3. 1151507Species Bacillus subtilis [TaxId:1423] [189591] (2 PDB entries)
    4. 1151513Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    5. 1151550Species Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    6. 1151559Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
      Uniprot Q9BJJ9 96-424 # fragment
    7. 1151607Species Mycobacterium leprae [TaxId:1769] [187924] (1 PDB entry)
    8. 1151610Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (39 PDB entries)
    9. 1151691Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    10. 1151697Species Staphylococcus aureus [TaxId:1280] [189086] (3 PDB entries)
    11. 1151705Species Thermus thermophilus [TaxId:274] [117409] (1 PDB entry)
      Uniprot Q5SLI9
  32. 1151710Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
  33. 1151716GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  34. 1151726GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 1151727Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 1151729Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
    3. 1151734Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 1151739Species Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  35. 1151746GDP-mannose-3', 5'-epimerase [141890] (1 species)
  36. 1151752Gluconate 5-dehydrogenase [110411] (1 species)
  37. 1151756Glucose dehydrogenase [51784] (1 species)
  38. 1151774Glucose dehydrogenase (5l265) [102155] (1 species)
  39. 1151777Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  40. 1151809Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  41. 1151834Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  42. 1151844Hypothetical protein F25D1.5 [110415] (1 species)
  43. 1151848Hypothetical protein PA4017 [141911] (1 species)
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
  44. 1151852Hypothetical protein R05D8.7 [117415] (1 species)
  45. 1151858Hypothetical protein TTHA0369 [141896] (1 species)
    TT0321
  46. 1151861Levodione reductase [89523] (1 species)
  47. 1151871Mannitol dehydrogenase [63927] (1 species)
  48. 1151885meso-2,3-butanediol dehydrogenase [51786] (1 species)
  49. 1151895Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  50. 1151903Peroxisomal multifunctional enzyme type 2 [141900] (1 species)
    17-beta-hydroxysteroid dehydrogenase 4
  51. 1151911Peroxisomal trans 2-enoyl CoA reductase [141884] (1 species)
  52. 1151917Phenylcoumaran benzylic ether reductase [102140] (1 species)
  53. 1151921Pinoresinol-lariciresinol reductase [102142] (1 species)
  54. 1151927Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  55. 1151941Putative carbonyl reductase sniffer [141913] (1 species)
  56. 1151944Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  57. 1151950Putative oxidoreductase Rv2002 [82292] (1 species)
  58. 1151962R-specific alcohol dehydrogenase [89521] (1 species)
  59. 1151966Retinal dehydrogenase/reductase 3 [141907] (1 species)
  60. 1151969Rhizome secoisolariciresinol dehydrogenase [141898] (1 species)
  61. 1151972Sepiapterin reductase [51767] (2 species)
    1. 1151973Species Human (Homo sapiens) [TaxId:9606] [141874] (1 PDB entry)
      Uniprot P35270 5-261
    2. 1151980Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
  62. 1151984Sorbitol dehydrogenase [102148] (1 species)
  63. 1151988Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  64. 1151994TAT-interacting protein TIP30 [141904] (2 species)
    1. 1151995Species Human (Homo sapiens) [TaxId:9606] [141905] (1 PDB entry)
      Uniprot Q9BUP3 5-236
    2. 1151997Species Mouse (Mus musculus) [TaxId:10090] [141906] (1 PDB entry)
      Uniprot Q9Z2G9 7-236
  65. 1151999Tropinone reductase [51795] (3 species)
    1. 1152000Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 1152003Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 1152011Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (1 PDB entry)
      Uniprot Q9ASX2
  66. 1152013Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 1152014Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
      Uniprot Q99714
    2. 1152020Species Norway rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 1152033Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  67. 1152036UDP-glucuronate decarboxylase 1 [141880] (1 species)
  68. 1152039UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  69. 1152043Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)
    1. 1152044Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
      Uniprot P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
    2. 1152046Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    3. 1152065Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    4. 1152079Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [89519] (1 PDB entry)
  70. 1152084Xylitol dehydrogenase [141882] (1 species)
  71. 1152087automated matches [190085] (34 species)
    not a true protein
    1. 1152088Species Alcaligenes faecalis [TaxId:511] [188427] (1 PDB entry)
    2. 1152091Species Alfalfa (Medicago sativa) [TaxId:3879] [187740] (1 PDB entry)
    3. 1152094Species Aquifex aeolicus [TaxId:224324] [188271] (2 PDB entries)
    4. 1152103Species Bacillus anthracis [TaxId:198094] [188031] (1 PDB entry)
    5. 1152112Species Bacillus megaterium [TaxId:1404] [195340] (3 PDB entries)
    6. 1152117Species Burkholderia pseudomallei [TaxId:320372] [188614] (1 PDB entry)
    7. 1152122Species Comamonas testosteroni [TaxId:285] [189779] (3 PDB entries)
    8. 1152129Species Eimeria tenella [TaxId:413949] [187997] (1 PDB entry)
    9. 1152132Species Emericella nidulans [TaxId:162425] [187249] (3 PDB entries)
    10. 1152157Species Escherichia coli K-12 [TaxId:83333] [189924] (3 PDB entries)
    11. 1152164Species Francisella tularensis [TaxId:177416] [189289] (1 PDB entry)
    12. 1152169Species Francisella tularensis [TaxId:263] [188795] (1 PDB entry)
    13. 1152174Species Human (Homo sapiens) [TaxId:9606] [186828] (5 PDB entries)
    14. 1152199Species Lactobacillus brevis [TaxId:1580] [186912] (6 PDB entries)
    15. 1152213Species Leishmania donovani [TaxId:5661] [189607] (1 PDB entry)
    16. 1152216Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [186807] (1 PDB entry)
    17. 1152218Species Pandoraea pnomenusa [TaxId:93220] [189780] (3 PDB entries)
    18. 1152225Species Plasmodium berghei [TaxId:5821] [189246] (1 PDB entry)
    19. 1152230Species Plesiomonas shigelloides [TaxId:703] [189972] (8 PDB entries)
    20. 1152261Species Pseudomonas fragi [TaxId:296] [188080] (6 PDB entries)
    21. 1152280Species Pseudomonas putida [TaxId:303] [188252] (2 PDB entries)
    22. 1152283Species Rhizobium radiobacter [TaxId:358] [197100] (1 PDB entry)
    23. 1152285Species Sinorhizobium meliloti [TaxId:266834] [195628] (1 PDB entry)
    24. 1152288Species Staphylococcus aureus [TaxId:282458] [193773] (1 PDB entry)
    25. 1152290Species Streptomyces coelicolor [TaxId:1902] [189970] (5 PDB entries)
    26. 1152298Species Streptomyces griseoruber [TaxId:1943] [196180] (1 PDB entry)
    27. 1152300Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [187183] (5 PDB entries)
    28. 1152306Species Thermus thermophilus [TaxId:274] [187600] (1 PDB entry)
    29. 1152310Species Thermus thermophilus [TaxId:300852] [187188] (4 PDB entries)
    30. 1152331Species Toxoplasma gondii [TaxId:383379] [187942] (2 PDB entries)
    31. 1152336Species Trypanosoma brucei [TaxId:5702] [187520] (4 PDB entries)
    32. 1152353Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [187036] (1 PDB entry)
    33. 1152358Species Vibrio cholerae [TaxId:243277] [189479] (7 PDB entries)
    34. 1152371Species Vibrio cholerae [TaxId:593588] [189768] (3 PDB entries)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: