Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) |
Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins) also known as short-chain dehydrogenases and SDR family parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 |
Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species) |
Species Human (Homo sapiens) [TaxId:9606] [117424] (24 PDB entries) Uniprot P28845 |
Domain d1xu7a_: 1xu7 A: [116048] complexed with cps, ndp |
Domain d1xu7b_: 1xu7 B: [116049] complexed with cps, ndp |
Domain d1xu7c_: 1xu7 C: [116050] complexed with cps, ndp |
Domain d1xu7d_: 1xu7 D: [116051] complexed with cps, ndp |
Domain d1xu9a_: 1xu9 A: [116052] complexed with cps, mes, ndp |
Domain d1xu9b_: 1xu9 B: [116053] complexed with cps, mes, ndp |
Domain d1xu9c_: 1xu9 C: [116054] complexed with cps, mes, ndp |
Domain d1xu9d_: 1xu9 D: [116055] complexed with cps, mes, ndp |
Domain d2bela_: 2bel A: [116694] complexed with cbo, cl, nap |
Domain d2belb_: 2bel B: [116695] complexed with cbo, cl, nap |
Domain d2belc_: 2bel C: [116696] complexed with cbo, cl, nap |
Domain d2beld_: 2bel D: [116697] complexed with cbo, cl, nap |
Domain d2ilta_: 2ilt A: [165610] automated match to d1xu9a_ complexed with nap, ni, nn1 |
Domain d2irwa1: 2irw A:26-289 [137593] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwb1: 2irw B:26-289 [137594] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwc1: 2irw C:26-282 [137595] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwd1: 2irw D:26-289 [137596] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwe1: 2irw E:26-282 [137597] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwf1: 2irw F:26-289 [137598] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwg1: 2irw G:26-289 [137599] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwh1: 2irw H:26-289 [137600] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2rbea_: 2rbe A: [151846] automated match to d1xu9a_ complexed with ndp, zmg |
Domain d2rbeb_: 2rbe B: [151847] automated match to d1xu9a_ complexed with ndp, zmg |
Domain d2rbec_: 2rbe C: [151848] automated match to d1xu9a_ complexed with ndp, zmg |
Domain d2rbed_: 2rbe D: [151849] automated match to d1xu9a_ complexed with ndp, zmg |
Domain d3byza_: 3byz A: [155734] automated match to d1xu9a_ complexed with h11, ndp |
Domain d3byzb_: 3byz B: [155735] automated match to d1xu9a_ complexed with h11, ndp |
Domain d3byzc_: 3byz C: [155736] automated match to d1xu9a_ complexed with h11, ndp |
Domain d3byzd_: 3byz D: [155737] automated match to d1xu9a_ complexed with h11, ndp |
Domain d3bzua_: 3bzu A: [155788] automated match to d1xu9a_ complexed with a21, nap |
Domain d3bzub_: 3bzu B: [155789] automated match to d1xu9a_ complexed with a21, nap |
Domain d3bzuc_: 3bzu C: [155790] automated match to d1xu9a_ complexed with a21, nap |
Domain d3bzud_: 3bzu D: [155791] automated match to d1xu9a_ complexed with a21, nap |
Domain d3ch6a_: 3ch6 A: [173241] automated match to d1xu9a_ complexed with 311, nap; mutant |
Domain d3ch6b_: 3ch6 B: [173242] automated match to d1xu9a_ complexed with 311, nap; mutant |
Domain d3ch6d_: 3ch6 D: [173243] automated match to d1xu9a_ complexed with 311, nap; mutant |
Domain d3ch6e_: 3ch6 E: [173244] automated match to d1xu9a_ complexed with 311, nap; mutant |
Domain d3czra_: 3czr A: [157154] automated match to d1xu9a_ complexed with 3cz, cps, nap |
Domain d3czrb_: 3czr B: [157155] automated match to d1xu9a_ complexed with 3cz, cps, nap |
Domain d3d3ea_: 3d3e A: [157280] automated match to d1xu9a_ complexed with d3e, nap |
Domain d3d3eb_: 3d3e B: [157281] automated match to d1xu9a_ complexed with d3e, nap |
Domain d3d3ec_: 3d3e C: [157282] automated match to d1xu9a_ complexed with d3e, nap |
Domain d3d3ed_: 3d3e D: [157283] automated match to d1xu9a_ complexed with d3e, nap |
Domain d3d4na_: 3d4n A: [157296] automated match to d1xu9a_ complexed with d4n, nap |
Domain d3d4nb_: 3d4n B: [157297] automated match to d1xu9a_ complexed with d4n, nap |
Domain d3d4nc_: 3d4n C: [157298] automated match to d1xu9a_ complexed with d4n, nap |
Domain d3d4nd_: 3d4n D: [157299] automated match to d1xu9a_ complexed with d4n, nap |
Domain d3d5qa_: 3d5q A: [157399] automated match to d1xu9a_ complexed with nap, t30 |
Domain d3d5qb_: 3d5q B: [157400] automated match to d1xu9a_ complexed with nap, t30 |
Domain d3d5qc_: 3d5q C: [157401] automated match to d1xu9a_ complexed with nap, t30 |
Domain d3d5qd_: 3d5q D: [157402] automated match to d1xu9a_ complexed with nap, t30 |
Domain d3fcoa_: 3fco A: [175688] automated match to d1xu9a_ complexed with iig, nap |
Domain d3fcob_: 3fco B: [175689] automated match to d1xu9a_ complexed with iig, nap |
Domain d3frja_: 3frj A: [176002] automated match to d1xu9a_ complexed with a49, nap |
Domain d3frjb_: 3frj B: [176003] automated match to d1xu9a_ complexed with a49, nap |
Domain d3h6ka_: 3h6k A: [177284] automated match to d1xu9a_ complexed with 33t, nap |
Domain d3h6kb_: 3h6k B: [177285] automated match to d1xu9a_ complexed with 33t, nap |
Domain d3h6kc_: 3h6k C: [177286] automated match to d1xu9a_ complexed with 33t, nap |
Domain d3h6kd_: 3h6k D: [177287] automated match to d1xu9a_ complexed with 33t, nap |
Domain d3hfga_: 3hfg A: [177530] automated match to d1xu9a_ complexed with 17r, nap |
Domain d3hfgb_: 3hfg B: [177531] automated match to d1xu9a_ complexed with 17r, nap |
Domain d3hfgc_: 3hfg C: [177532] automated match to d1xu9a_ complexed with 17r, nap |
Domain d3hfgd_: 3hfg D: [177533] automated match to d1xu9a_ complexed with 17r, nap |
Domain d3oq1a_: 3oq1 A: [214474] automated match to d1xu9a_ complexed with 3oq, nap |
Domain d3oq1b_: 3oq1 B: [214475] automated match to d1xu9a_ complexed with 3oq, nap |
Domain d3oq1c_: 3oq1 C: [214476] automated match to d1xu9a_ complexed with 3oq, nap |
Domain d3oq1d_: 3oq1 D: [214477] automated match to d1xu9a_ complexed with 3oq, nap |
Domain d3pdja_: 3pdj A: [183673] automated match to d1xu9b_ complexed with 3pj, nap |
Domain d3pdjb_: 3pdj B: [183674] automated match to d1xu9b_ complexed with 3pj, nap |
Domain d3qqpa_: 3qqp A: [215369] automated match to d1xu9b_ complexed with ndp, s05 |
Domain d3qqpb_: 3qqp B: [215370] automated match to d1xu9b_ complexed with ndp, s05 |
Domain d3qqpc_: 3qqp C: [215371] automated match to d1xu9b_ complexed with ndp, s05 |
Domain d3qqpd_: 3qqp D: [215372] automated match to d1xu9b_ complexed with ndp, s05 |
Domain d3tfqa_: 3tfq A: [185814] automated match to d1xu9a_ complexed with 07m, gol, nap; mutant |
Domain d3tfqb_: 3tfq B: [185815] automated match to d1xu9a_ complexed with 07m, gol, nap; mutant |
Domain d3tfqd_: 3tfq D: [185816] automated match to d1xu9a_ complexed with 07m, gol, nap; mutant |
Domain d3tfqe_: 3tfq E: [185817] automated match to d1xu9a_ complexed with 07m, gol, nap; mutant |
Domain d4hfra_: 4hfr A: [222558] automated match to d3pdjb_ complexed with 14m, nap |
Domain d4hfrb_: 4hfr B: [222559] automated match to d3pdjb_ complexed with 14m, nap |
Domain d4hx5a_: 4hx5 A: [197024] automated match to d3pdjb_ complexed with 19v, ndp |
Domain d4hx5b_: 4hx5 B: [197314] automated match to d3pdjb_ complexed with 19v, ndp |
Domain d4hx5c_: 4hx5 C: [197313] automated match to d3pdjb_ complexed with 19v, ndp |
Domain d4hx5d_: 4hx5 D: [202508] automated match to d1xu9b_ complexed with 19v, ndp |
Domain d4k1la_: 4k1l A: [238381] automated match to d1xu9a_ complexed with ndp, sff |
Domain d4k1lb_: 4k1l B: [238387] automated match to d1xu9b_ complexed with ndp, sff |
Domain d4k1lc_: 4k1l C: [238389] automated match to d1xu9a_ complexed with ndp, sff |
Domain d4k1ld_: 4k1l D: [238390] automated match to d1xu9b_ complexed with ndp, sff |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1: