SCOPe 2.08: Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators

Lineage for Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators [46894] (4 families)
   binds to DNA and RNA polymerase; the N-terminal, receiver domain belongs to the CheY family

Families:

1. a.4.6.1: PhoB-like [46895] (6 proteins)
   contains 4-stranded meander beta-sheet in the N-terminal extension

2. a.4.6.2: GerE-like (LuxR/UhpA family of transcriptional regulators) [46900] (5 proteins)
   contains additional, fourth helix in the C-terminal extension

3. a.4.6.3: Spo0A [46903] (1 protein)
   elaborated with additional helices
   automatically mapped to Pfam PF08769

4. a.4.6.0: automated matches [191513] (1 protein)
   not a true family

More info for Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators

Timeline for Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators:

• Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators first appeared (with stable ids) in SCOP 1.55, called Superfamily a.4.6: C-terminal, effector domain of the bipartite response regulators
  
• Superfamily a.4.6: C-terminal effector domain of the bipartite response regulators appears in SCOPe 2.07