SCOPe 2.07: Domain d2hira_: 2hir A:

Lineage for d2hira_ (2hir A:)

1. Root: SCOPe 2.07

2. Class g: Small proteins [56992] (98 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.15: Leech antihemostatic proteins [57262] (3 families)

5. Family g.3.15.2: Hirudin-like [57270] (4 proteins)

6. Protein Hirudin [57271] (1 species)

7. Species Medicinal leech (Hirudo medicinalis) [TaxId:6421] [57272] (9 PDB entries)

8. Domain d2hira_: 2hir A: [44372]
   mutant

Details for d2hira_

PDB Entry: 2hir

PDB Description: solution structure of recombinant hirudin and the lys-47 (right arrow) glu mutant. a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study

PDB Compounds: (A:) hirudin variant-1

SCOPe Domain Sequences for d2hira_:

Sequence; same for both SEQRES and ATOM records:

>d2hira_ g.3.15.2 (A:) Hirudin {Medicinal leech (Hirudo medicinalis) [TaxId: 6421]}
vvytdctesgqnlclcegsnvcgqgnkcilgsdgeknqcvtgegtpkpq

Timeline for d2hira_:

• d2hira_ first appeared (with stable ids) in SCOP 1.55, called d2hir__
  
• d2hira_ appears in SCOPe 2.06
  
• d2hira_ appears in the current release, SCOPe 2.08