SCOPe 2.05: Domain d1bxla_: 1bxl A:

Lineage for d1bxla_ (1bxl A:)

1. Root: SCOPe 2.05

2. Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein Apoptosis regulator Bcl-xL [56856] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56857] (32 PDB entries)

8. Domain d1bxla_: 1bxl A: [43396]

Details for d1bxla_

PDB Entry: 1bxl

PDB Description: structure of bcl-xl/bak peptide complex, nmr, minimized average structure

PDB Compounds: (A:) bcl-xl

SCOPe Domain Sequences for d1bxla_:

Sequence, based on SEQRES records:

>d1bxla_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
msmamsqsnrelvvdflsyklsqkgyswsqfsdveenrteapegtesemetpsaingnps
whladspavngatghsssldarevipmaavkqalreagdefelryrrafsdltsqlhitp
gtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylnd
hlepwiqenggwdtfvelygnnaaaesrkgqerlehhhhhh

Sequence, based on observed residues (ATOM records):

>d1bxla_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
msmamsqsnrelvvdflsyklsqkgyswsqfsdveenrteapegteseavkqalreagde
felryrrafsdltsqlhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvd
kemqvlvsriaawmatylndhlepwiqenggwdtfvelygnnaaaesrkgqerlehhhhh
h

Timeline for d1bxla_:

• d1bxla_ first appeared (with stable ids) in SCOP 1.55
  
• d1bxla_ appears in SCOPe 2.04
  
• d1bxla_ is called d1bxla1 in SCOPe 2.06
  
• d1bxla_ appears in the current release, SCOPe 2.08, called d1bxla1