Lineage for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

  1. Root: SCOPe 2.05
  2. 1955192Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)
  3. 1955193Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 1955265Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 1955266Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
    Pfam PF00452

Proteins:

  1. 1955267Apoptosis regulator Bcl-w [90103] (1 species)
  2. 1955272Apoptosis regulator Bcl-xL [56856] (3 species)
    1. 1955273Species Human (Homo sapiens) [TaxId:9606] [56857] (32 PDB entries)
    2. 1955321Species Mouse (Mus musculus) [TaxId:10090] [103423] (9 PDB entries)
    3. 1955335Species Norway rat (Rattus norvegicus) [TaxId:10116] [56858] (1 PDB entry)
  3. 1955337Apoptosis regulator ced-9 [103424] (1 species)
  4. 1955343Bcl-2 [64524] (1 species)
  5. 1955358Bcl-2 homolog [75637] (1 species)
  6. 1955361Bcl-2 homolog V-bcl-2 [144081] (1 species)
  7. 1955368Early antigen protein R [103426] (1 species)
  8. 1955371EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (3 species)
    1. 1955372Species Human (Homo sapiens) [TaxId:9606] [188549] (1 PDB entry)
    2. 1955374Species Mouse (Mus musculus) [TaxId:10090] [118213] (5 PDB entries)
      Uniprot P97287 152-308
    3. 1955380Species Norway rat (Rattus norvegicus) [TaxId:10116] [187917] (2 PDB entries)
  9. 1955383Proapoptotic molecule Bax [56862] (1 species)
  10. 1955387Proapoptotic molecule Bid [56859] (2 species)
    1. 1955388Species Human (Homo sapiens) [TaxId:9606] [56860] (1 PDB entry)
    2. 1955390Species Mouse (Mus musculus) [TaxId:10090] [56861] (1 PDB entry)
  11. 1955392automated matches [190236] (3 species)
    not a true protein
    1. 1955393Species Human (Homo sapiens) [TaxId:9606] [188722] (38 PDB entries)
    2. 1955509Species Mouse (Mus musculus) [TaxId:10090] [187004] (1 PDB entry)
    3. 1955511Species Nematode (Caenorhabditis elegans) [TaxId:6239] [255025] (1 PDB entry)

More info for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

Timeline for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death: