Lineage for d6fmda_ (6fmd A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2826025Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2827845Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families) (S)
  5. 2827846Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)
  6. 2827891Protein Dihydroorotate dehydrogenase [51397] (8 species)
  7. 2827897Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)
  8. 2827916Domain d6fmda_: 6fmd A: [415952]
    automated match to d6i55b_
    complexed with act, cl, duh, fmn, gol, oro, pge

Details for d6fmda_

PDB Entry: 6fmd (more details), 1.58 Å

PDB Description: targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hdhodh) inhibitors based on 2-hydroxypyrazolo[1,5- a]pyridine scaffold
PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d6fmda_:

Sequence, based on SEQRES records: (download)

>d6fmda_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
vnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedias
vvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpi
igvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdai
gadhrr

Sequence, based on observed residues (ATOM records): (download)

>d6fmda_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
vnvsspgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidg
livtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssg
qdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

SCOPe Domain Coordinates for d6fmda_:

Click to download the PDB-style file with coordinates for d6fmda_.
(The format of our PDB-style files is described here.)

Timeline for d6fmda_:

  • d6fmda_ is new in SCOPe 2.08-stable