PDB entry 6fmd

View 6fmd on RCSB PDB site
Description: Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold
Class: oxidoreductase
Keywords: DHODH, inhibitor complex, OXIDOREDUCTASE
Deposited on 2018-01-30, released 2018-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-08, with a file datestamp of 2018-08-03.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6fmda_
  • Heterogens: DUH, CL, FMN, ACT, ORO, GOL, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6fmdA (A:)
mawrhlkkraqdaviilggggllfasylmatgderfyaehlmptlqglldpesahrlavr
ftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsv
tpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvn
lgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqer
dglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrset
gglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltf
wgppvvgkvkreleallkeqgfggvtdaigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6fmdA (A:)
atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
vnvsspgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidg
livtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssg
qdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr