SCOPe 2.08: Domain d6xxia_: 6xxi A:

Lineage for d6xxia_ (6xxi A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.1: Deoxyhypusine synthase, DHS [52468] (2 proteins)
   automatically mapped to Pfam PF01916

6. Protein Deoxyhypusine synthase, DHS [52469] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52470] (14 PDB entries)
   Uniprot P49366

8. Domain d6xxia_: 6xxi A: [383924]
   automated match to d1rlza_
   complexed with act, bme, edo, fmt, mrd, nad

Details for d6xxia_

PDB Entry: 6xxi, 1.68 Å

PDB Description: crystal structure of human deoxyhypusine synthase in complex with nad

PDB Compounds: (A:) deoxyhypusine synthase

SCOPe Domain Sequences for d6xxia_:

Sequence, based on SEQRES records:

>d6xxia_ c.31.1.1 (A:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqhadl
tqsrrpltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclapty
lgefslrgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmi
arlgkeinnpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlin
tqaifakctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavsw
gkirvdaqpvkvyadaslvfpllvaetfaqkmdafm

Sequence, based on observed residues (ATOM records):

>d6xxia_ c.31.1.1 (A:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplhadltqsrrp
ltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefsl
rgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgke
innpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifa
kctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavswgkirvd
aqpvkvyadaslvfpllvaetfaqkmdafm

Timeline for d6xxia_:

• d6xxia_ first appeared in SCOPe 2.07