PDB entry 6xxi

View 6xxi on RCSB PDB site
Description: Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD
Class: transferase
Keywords: hypusination, deoxyhypusine synthase, EIF5A, translation, hypusine, posttranslational modification, polyamines, deoxyhypusine, TRANSFERASE
Deposited on 2020-01-27, released 2020-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-15, with a file datestamp of 2020-04-10.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: deoxyhypusine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHPS, DS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xxia_
  • Chain 'B':
    Compound: deoxyhypusine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHPS, DS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xxib_
  • Heterogens: NAD, ACT, EDO, BME, FMT, MRD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xxiA (A:)
megslereapagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqatnfg
ravqqvnamiekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretirylv
qhnmvdvlvttaggveedlikclaptylgefslrgkelrenginrignllvpnenyckfe
dwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspaltdgs
lgdmiffhsyknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmrnga
dyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaqkmd
afmhekned

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxiA (A:)
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplhadltqsrrp
ltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefsl
rgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgke
innpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifa
kctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavswgkirvd
aqpvkvyadaslvfpllvaetfaqkmdafm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xxiB (B:)
megslereapagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqatnfg
ravqqvnamiekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretirylv
qhnmvdvlvttaggveedlikclaptylgefslrgkelrenginrignllvpnenyckfe
dwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspaltdgs
lgdmiffhsyknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmrnga
dyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaqkmd
afmhekned

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxiB (B:)
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqhadl
tqsrrpltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclapty
lgefslrgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmi
arlgkeinnpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlin
tqaifakctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavsw
gkirvdaqpvkvyadaslvfpllvaetfaqkmdafmh