SCOPe 2.08: Domain d6bgtc3: 6bgt C:323-488

Lineage for d6bgtc3 (6bgt C:323-488)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.10: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3 superfamilies)
   2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies

4. Superfamily c.10.2: L domain-like [52058] (9 families)
   less regular structure consisting of variable repeats

5. Family c.10.2.0: automated matches [191489] (1 protein)
   not a true family

6. Protein automated matches [190787] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188042] (21 PDB entries)

8. Domain d6bgtc3: 6bgt C:323-488 [359499]
   Other proteins in same PDB: d6bgta1, d6bgta2, d6bgtb_, d6bgtc2, d6bgtc4
   automated match to d1n8zc2
   complexed with nag; mutant

Details for d6bgtc3

PDB Entry: 6bgt, 2.7 Å

PDB Description: structure of trastuzumab fab mutant in complex with her2 extracellular domain

PDB Compounds: (C:) Receptor tyrosine-protein kinase erbB-2

SCOPe Domain Sequences for d6bgtc3:

Sequence; same for both SEQRES and ATOM records:

>d6bgtc3 c.10.2.0 (C:323-488) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplqpeqlqvfetle
eitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlglrslrelgsg
lalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgegla

Timeline for d6bgtc3:

• d6bgtc3 first appeared in SCOPe 2.07