SCOPe 2.08: Domain d6g31c_: 6g31 C:

Lineage for d6g31c_ (6g31 C:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein Geranylgeranyl pyrophosphate synthetase [158813] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158814] (5 PDB entries)
   Uniprot O95749 6-296

8. Domain d6g31c_: 6g31 C: [358943]
   automated match to d2q80a1
   complexed with mg, zol; mutant

Details for d6g31c_

PDB Entry: 6g31, 3 Å

PDB Description: crystal structure of human geranylgeranyl diphosphate synthase mutant d188y bound to zoledronate

PDB Compounds: (C:) Geranylgeranyl pyrophosphate synthase

SCOPe Domain Sequences for d6g31c_:

Sequence, based on SEQRES records:

>d6g31c_ a.128.1.1 (C:) Geranylgeranyl pyrophosphate synthetase {Human (Homo sapiens) [TaxId: 9606]}
tqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnaslli
ddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelh
qgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglf
fqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidi
kkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

Sequence, based on observed residues (ATOM records):

>d6g31c_ a.128.1.1 (C:) Geranylgeranyl pyrophosphate synthetase {Human (Homo sapiens) [TaxId: 9606]}
tqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnaslli
ddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelh
qgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglf
fqirydyanlhsnksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycv
hyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

Timeline for d6g31c_:

• d6g31c_ first appeared in SCOPe 2.07