PDB entry 6g31

View 6g31 on RCSB PDB site
Description: Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate
Class: transferase
Keywords: geranylgeranyl diphosphate synthase, mevalonate pathway, prenyltransferase, GGPPS, bisphosphonates, TRANSFERASE
Deposited on 2018-03-24, released 2018-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-07, with a file datestamp of 2018-11-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31a_
  • Chain 'B':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31b_
  • Chain 'C':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31c_
  • Chain 'D':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31d_
  • Chain 'E':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31e_
  • Chain 'F':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31f_
  • Chain 'G':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31g_
  • Chain 'H':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31h_
  • Chain 'I':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31i_
  • Chain 'J':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31j_
  • Chain 'K':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31k_
  • Chain 'L':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • conflict (115)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6g31l_
  • Heterogens: ZOL, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6g31A (A:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31A (A:)
qetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllid
diednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhq
gqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglff
qirydyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhy
ledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6g31B (B:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31B (B:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irydyanlhssfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyle
dvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6g31C (C:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31C (C:)
tqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnaslli
ddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelh
qgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglf
fqirydyanlhsnksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycv
hyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6g31D (D:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31D (D:)
etvqrillepykyllqlpgtklsqafnhwlkvpedklqiiievtemlhnaslliddiedn
sklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqgqgld
iywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffqiryd
yanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyledvg
sfeytrntlkeleakaykqidarggnpelvalvkhlskmf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6g31E (E:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31E (E:)
qetvqrillepykyllqlafnhwlkvpedklqiiievtemlhnaslliddiednsklrrg
fpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqgqgldiywrdn
ytcpteeeykamvlqktgglfglavglmqlfsdykntlglffqirydyanlhsfcedlte
gkfsfptihaiwsrptqvqnilrqrtenidikkycvhygsfeytrntlkeleakpelval
vkhlskmfk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6g31F (F:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31F (F:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irydyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6g31G (G:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31G (G:)
ktqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasll
iddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllel
hqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykpllntlglffqi
rydyanlhsfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyledv
gsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6g31H (H:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31H (H:)
etvqrillepykyllqlpqvrtklsqafnhwlkvpedklqiiievtemlhnaslliddie
dnsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqgqg
ldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffqir
ydyanlhsfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyledvg
sfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6g31I (I:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31I (I:)
qetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllid
diednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhq
gqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglff
qirydyanlksfcedltegkfsfptihaiwsrpevqnilrqrtenidikkycvhyledvg
sfeytrntlkeleakaykqidgnpelvalvkhlskm

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6g31J (J:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31J (J:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irydyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6g31K (K:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31K (K:)
qetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllid
diednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhq
gqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykkpllntlglffqir
ydyanlhssfcedltegkfsfptihaiwsrpeqvqnilrqrtenidikkycvhyledvgy
trntlkeleakaykqpelvalvkhlskmf

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6g31L (L:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirydyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6g31L (L:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irydyanlhsfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyled
vgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk