SCOPe 2.07: Domain d6c1sa3: 6c1s A:544-725

Lineage for d6c1sa3 (6c1s A:544-725)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (27 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (77 PDB entries)

8. Domain d6c1sa3: 6c1s A:544-725 [353852]
   Other proteins in same PDB: d6c1sa1, d6c1sa2, d6c1sa4
   automated match to d1e8ya1
   complexed with efv, so4

Details for d6c1sa3

PDB Entry: 6c1s, 2.31 Å

PDB Description: phosphoinositide 3-kinase gamma bound to an pyrrolopyridinone inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d6c1sa3:

Sequence; same for both SEQRES and ATOM records:

>d6c1sa3 a.118.1.6 (A:544-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
raempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqei
vaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllql
vqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrg
cg

Timeline for d6c1sa3:

• d6c1sa3 is new in SCOPe 2.07-stable
  
• d6c1sa3 appears in the current release, SCOPe 2.08