SCOPe 2.07: Domain d6c1sa1: 6c1s A:144-321

Lineage for d6c1sa1 (6c1s A:144-321)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d6c1sa1: 6c1s A:144-321 [353849]
   Other proteins in same PDB: d6c1sa2, d6c1sa3, d6c1sa4
   automated match to d1he8a3
   complexed with efv, so4

Details for d6c1sa1

PDB Entry: 6c1s, 2.31 Å

PDB Description: phosphoinositide 3-kinase gamma bound to an pyrrolopyridinone inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d6c1sa1:

Sequence, based on SEQRES records:

>d6c1sa1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d6c1sa1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkvlrvcgrdeylv
getpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d6c1sa1:

• d6c1sa1 is new in SCOPe 2.07-stable
  
• d6c1sa1 appears in the current release, SCOPe 2.08