PDB entry 6c1s

View 6c1s on RCSB PDB site
Description: Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor
Class: Transferase/Transferase Inhibitor
Keywords: kinase, inhibitor, Transferase-Transferase Inhibitor complex
Deposited on 2018-01-05, released 2018-06-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-06-27, with a file datestamp of 2018-06-22.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c1sa1, d6c1sa2, d6c1sa3, d6c1sa4
  • Heterogens: EFV, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6c1sA (A:)
mpmaseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamh
pwvtskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslm
dipesqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevr
keewplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdl
tvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkap
alsskasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfna
dkltsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaii
atdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdq
saldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalar
fllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvi
emlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaie
kckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetes
ldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkeksptee
kfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflgin
kervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgm
pqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgek
hsalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6c1sA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkvlrvcgrdeylv
getpiknfqwvrhclkngeeihvvldtppdpaldevrkecdrkfrvkirgidipvltdlt
vfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycvqlly
yvnlllidhrfllrrgeyvlhmwqisgsfnadkltsatnpdkensmsisilldnraempn
qlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyq
llarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkf
epyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtaml
hdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydp
glkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilr
imesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntfkdevlnhwl
kekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghiker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpts
kedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhl