SCOPe 2.02: Domain d1dr0a_: 1dr0 A:

Lineage for d1dr0a_ (1dr0 A:)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein 3-isopropylmalate dehydrogenase, IPMDH [53661] (10 species)

7. Species Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)

8. Domain d1dr0a_: 1dr0 A: [35045]

Details for d1dr0a_

PDB Entry: 1dr0, 2.2 Å

PDB Description: structure of modified 3-isopropylmalate dehydrogenase at the c- terminus, hd708

PDB Compounds: (A:) 3-isopropylmalate dehydrogenase

SCOPe Domain Sequences for d1dr0a_:

Sequence; same for both SEQRES and ATOM records:

>d1dr0a_ c.77.1.1 (A:) 3-isopropylmalate dehydrogenase, IPMDH {Thermus thermophilus [TaxId: 274]}
mkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrkg
veeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplke
eiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafelarkrrkhv
vsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnifg
dilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammleh
afglvelarkvedavakalletpppdlggsagteaftatvtatvgi

Timeline for d1dr0a_:

• d1dr0a_ first appeared (with stable ids) in SCOP 1.55
  
• d1dr0a_ appears in SCOPe 2.01
  
• d1dr0a_ appears in SCOPe 2.03
  
• d1dr0a_ appears in the current release, SCOPe 2.08