SCOP 1.63: Domain d1axgd2: 1axg D:175-324

Lineage for d1axgd2 (1axg D:175-324)

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain [51736] (6 proteins)
   N-terminal all-beta domain defines family

6. Protein Alcohol dehydrogenase [51737] (5 species)

7. Species Horse (Equus caballus) [TaxId:9796] [51738] (30 PDB entries)

8. Domain d1axgd2: 1axg D:175-324 [29710]
   Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
   complexed with etf, nad, zn; mutant

Details for d1axgd2

PDB Entry: 1axg, 2.5 Å

PDB Description: crystal structure of the val203->ala mutant of liver alcohol dehydrogenase complexed with cofactor nad and inhibitor trifluoroethanol solved to 2.5 angstrom resolution

SCOP Domain Sequences for d1axgd2:

Sequence; same for both SEQRES and ATOM records:

>d1axgd2 c.2.1.1 (D:175-324) Alcohol dehydrogenase {Horse (Equus caballus)}
gfstgygsavkvakvtqgstcavfglggaglsvimgckaagaariigvdinkdkfakake
vgatecvnpqdykkpiqevltemsnggvdfsfevigrldtmvtalsccqeaygvsvivgv
ppdsqnlsmnpmlllsgrtwkgaifggfks

Timeline for d1axgd2:

• d1axgd2 first appeared (with stable ids) in SCOP 1.55
  
• d1axgd2 appears in SCOP 1.61
  
• d1axgd2 appears in SCOP 1.65
  
• d1axgd2 appears in the current release, SCOPe 2.08