SCOPe 2.07: Domain d2f8sa4: 2f8s A:488-706

Lineage for d2f8sa4 (2f8s A:488-706)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (16 families)
   consists of one domain of this fold

5. Family c.55.3.15: PIWI domain C-terminal [310608] (4 proteins)
   PubMed 15565169 notes that both halves of PIWI are usually a single evolutionary unit; however, fragments have been characterized separately. The N-terminal half is (c.44.3.1)

6. Protein Argonaute homologue Aq_1447 [310683] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [310900] (4 PDB entries)

8. Domain d2f8sa4: 2f8s A:488-706 [286905]
   Other proteins in same PDB: d2f8sa1, d2f8sa3, d2f8sb1, d2f8sb3
   protein/RNA complex

Details for d2f8sa4

PDB Entry: 2f8s, 3 Å

PDB Description: Crystal structure of Aa-Ago with externally-bound siRNA

PDB Compounds: (A:) Argonaute protein

SCOPe Domain Sequences for d2f8sa4:

Sequence; same for both SEQRES and ATOM records:

>d2f8sa4 c.55.3.15 (A:488-706) Argonaute homologue Aq_1447 {Aquifex aeolicus [TaxId: 63363]}
lkeiegkvdafvgidisritrdgktvnavaftkifnskgelvryyltsypafgeklteka
igdvfslleklgfkkgskivvhrdgrlyrdevaafkkygelygyslelleiikrnnprff
snekfikgyfyklsedsvilatynqvyegthqpikvrkvygelpvevlcsqilsltlmny
ssfqpiklpatvhysdkitklmlrgiepikkegdimywl

Timeline for d2f8sa4:

• d2f8sa4 first appeared in SCOPe 2.06
  
• d2f8sa4 appears in the current release, SCOPe 2.08