SCOPe 2.08: Domain d2pnra3: 2pnr A:174-400

Lineage for d2pnra3 (2pnr A:174-400)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (19 PDB entries)
   Uniprot Q15120 177-301

8. Domain d2pnra3: 2pnr A:174-400 [262230]
   Other proteins in same PDB: d2pnra1, d2pnrb1, d2pnrc_, d2pnre1, d2pnrf1, d2pnrg_
   automated match to d2pnrb2
   complexed with red

Details for d2pnra3

PDB Entry: 2pnr, 2.5 Å

PDB Description: Crystal Structure of the asymmetric Pdk3-l2 Complex

PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3

SCOPe Domain Sequences for d2pnra3:

Sequence, based on SEQRES records:

>d2pnra3 d.122.1.4 (A:174-400) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiq
vvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisdlgggvp
lrkidrlfnymystaprpsleptraaplagfgyglpisrlyaryfqgdlklysmegvgtd
aviylkalssesferlpvfnksawrhykttpeaddwsnpsseprdas

Sequence, based on observed residues (ATOM records):

>d2pnra3 d.122.1.4 (A:174-400) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiq
vvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisdlgggvp
lrkidrlfnyaaplagfgyglpisrlyaryfqgdlklysmegvgtdaviylkalssesfe
rlpvfnksawrhykttpeaddwsnpsseprdas

Timeline for d2pnra3:

• d2pnra3 first appeared in SCOPe 2.05
  
• d2pnra3 appears in SCOPe 2.07